Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | CSNK2A1 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] (391 aa) | ||
 | FTSJ2 | FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase (246 aa) | ||
 | RRP36 | ribosomal RNA processing 36 homolog (S. cerevisiae); Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA (259 aa) | ||
 | RPS16 | ribosomal protein S16 (146 aa) | ||
 | MRPS9 | mitochondrial ribosomal protein S9 (396 aa) | ||
 | DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (547 aa) | ||
 | WDR74 | WD repeat domain 74 (385 aa) | ||
 | MKI67IP | MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa) | ||
 | NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae); Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity) (260 aa) | ||
 | HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) (306 aa) | ||
 | FTSJ1 | FtsJ RNA methyltransferase homolog 1 (E. coli) (329 aa) | ||
 | BRIX1 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit (353 aa) | ||
 | RRP1B | ribosomal RNA processing 1 homolog B (S. cerevisiae) (758 aa) | ||
 | GTPBP4 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) (634 aa) | ||
 | RRP15 | ribosomal RNA processing 15 homolog (S. cerevisiae) (282 aa) | ||
 | SURF6 | surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) (361 aa) | ||
 | UTP11L | UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (253 aa) | ||
 | PAK1IP1 | PAK1 interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42 (392 aa) | ||
 | ENSG00000243207 | PPAN-P2RY11 readthrough (794 aa) | ||
 | RPS8 | ribosomal protein S8 (208 aa) | ||
 | FTSJ3 | FtsJ homolog 3 (E. coli); Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation (847 aa) | ||
 | DAZ4 | deleted in azoospermia 4; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation (579 aa) | ||
 | EBNA1BP2 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) (361 aa) | ||
 | RRP1 | ribosomal RNA processing 1 homolog (S. cerevisiae); Plays a critical role in the generation of 28S rRNA (461 aa) | ||
 | PPAN | peter pan homolog (Drosophila); Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP (794 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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