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TRIB3 | tribbles homolog 3 (Drosophila); Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the ’Thr-308’ phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display k [...] (358 aa) | |||
CSNK2A1 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] (391 aa) | |||
HIST1H1A | histone cluster 1, H1a; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity) (215 aa) | |||
RPS16 | ribosomal protein S16 (146 aa) | |||
LIN28A | lin-28 homolog A (C. elegans); Acts as a ’translational enhancer’, driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) [...] (209 aa) | |||
MRPS9 | mitochondrial ribosomal protein S9 (396 aa) | |||
DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (547 aa) | |||
PRR11 | proline rich 11 (360 aa) | |||
CSNK2A2 | casein kinase 2, alpha prime polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly [...] (350 aa) | |||
MKI67IP | MKI67 (FHA domain) interacting nucleolar phosphoprotein (293 aa) | |||
NSA2 | NSA2 ribosome biogenesis homolog (S. cerevisiae); Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity) (260 aa) | |||
NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) (294 aa) | |||
COG5 | component of oligomeric golgi complex 5; Required for normal Golgi function (By similarity) (860 aa) | |||
TERT | telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3’-chromosomal termini with the 6- n [...] (1132 aa) | |||
NIM1 | Serine/threonine-protein kinase NIM1 (436 aa) | |||
RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); Involved in ribosome biogenesis (By similarity) (365 aa) | |||
RPL14 | ribosomal protein L14 (215 aa) | |||
NOL12 | nucleolar protein 12; May bind to 28S rRNA (By similarity) (213 aa) | |||
RRP15 | ribosomal RNA processing 15 homolog (S. cerevisiae) (282 aa) | |||
SURF6 | surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) (361 aa) | |||
UTP11L | UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (253 aa) | |||
PIM1 | pim-1 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergi [...] (313 aa) | |||
ENSG00000243207 | PPAN-P2RY11 readthrough (794 aa) | |||
RPS8 | ribosomal protein S8 (208 aa) | |||
EBNA1BP2 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) (361 aa) | |||
PPAN | peter pan homolog (Drosophila); Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP (794 aa) |