node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAMBI | BMP2 | ENSP00000364683 | ENSP00000368104 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.929 |
BAMBI | BMP4 | ENSP00000364683 | ENSP00000245451 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.944 |
BAMBI | BMPR1A | ENSP00000364683 | ENSP00000224764 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | 0.968 |
BAMBI | BMPR1B | ENSP00000364683 | ENSP00000264568 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein receptor, type IB; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5 | 0.967 |
BAMBI | BMPR2 | ENSP00000364683 | ENSP00000363708 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | bone morphogenetic protein receptor, type II (serine/threonine kinase); On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs | 0.933 |
BAMBI | CER1 | ENSP00000364683 | ENSP00000370297 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis); Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity) | 0.905 |
BAMBI | CHRDL1 | ENSP00000364683 | ENSP00000361112 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | chordin-like 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment e [...] | 0.902 |
BAMBI | NOG | ENSP00000364683 | ENSP00000328181 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | 0.938 |
BAMBI | RGMA | ENSP00000364683 | ENSP00000452126 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | RGM domain family, member A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivati [...] | 0.901 |
BAMBI | RGMB | ENSP00000364683 | ENSP00000308219 | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | RGM domain family, member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth | 0.914 |
BMP2 | BAMBI | ENSP00000368104 | ENSP00000364683 | bone morphogenetic protein 2; Induces cartilage and bone formation | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis); Negatively regulates TGF-beta signaling (By similarity) | 0.929 |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | BMPR1A | ENSP00000368104 | ENSP00000224764 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | 0.999 |
BMP2 | BMPR1B | ENSP00000368104 | ENSP00000264568 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type IB; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5 | 0.999 |
BMP2 | BMPR2 | ENSP00000368104 | ENSP00000363708 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type II (serine/threonine kinase); On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs | 0.998 |
BMP2 | CER1 | ENSP00000368104 | ENSP00000370297 | bone morphogenetic protein 2; Induces cartilage and bone formation | cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis); Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity) | 0.919 |
BMP2 | CHRDL1 | ENSP00000368104 | ENSP00000361112 | bone morphogenetic protein 2; Induces cartilage and bone formation | chordin-like 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment e [...] | 0.913 |
BMP2 | FSTL1 | ENSP00000368104 | ENSP00000295633 | bone morphogenetic protein 2; Induces cartilage and bone formation | follistatin-like 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity) | 0.958 |
BMP2 | GREM2 | ENSP00000368104 | ENSP00000318650 | bone morphogenetic protein 2; Induces cartilage and bone formation | gremlin 2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells (By similarity) | 0.993 |
BMP2 | NOG | ENSP00000368104 | ENSP00000328181 | bone morphogenetic protein 2; Induces cartilage and bone formation | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | 0.999 |