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PIK3R2 | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane (728 aa) | |||
USHBP1 | Usher syndrome 1C binding protein 1 (703 aa) | |||
MID2 | midline 2 (735 aa) | |||
TXNDC9 | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin (226 aa) | |||
NME5 | NME/NM23 family member 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity) (212 aa) | |||
DPY30 | dpy-30 homolog (C. elegans); As part of the MLL1/MLL complex, involved in the methylation of histone H3 at ’Lys-4’, particularly trimethylation. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci. May also play an indirect or direct role in endosomal transport (99 aa) | |||
ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic response element (XRE) (717 aa) | |||
MOS | v-mos Moloney murine sarcoma viral oncogene homolog (346 aa) | |||
ZGPAT | zinc finger, CCCH-type with G patch domain (531 aa) | |||
WAC | WW domain containing adaptor with coiled-coil (647 aa) | |||
TXLNB | taxilin beta; Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic (684 aa) | |||
DYDC1 | DPY30 domain containing 1; Plays a crucial role during acrosome biogenesis (177 aa) | |||
CCNC | cyclin C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylate [...] (283 aa) |