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STRINGSTRING
DNAJB6 DNAJB6 ENSG00000170276 ENSG00000170276 RPA1 RPA1 FKBP4 FKBP4 RPA2 RPA2 COL22A1 COL22A1 COL15A1 COL15A1 COL14A1 COL14A1 COL4A6 COL4A6 COL6A2 COL6A2 COL25A1 COL25A1 COL27A1 COL27A1 COL21A1 COL21A1 COL20A1 COL20A1 COL11A1 COL11A1 COL1A2 COL1A2 COL8A2 COL8A2 ITGA2 ITGA2 COL6A1 COL6A1 COL4A5 COL4A5 COL2A1 COL2A1 COL18A1 COL18A1 COL6A3 COL6A3 COL4A3 COL4A3 COL4A4 COL4A4 ITGA1 ITGA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
FKBP4FK506 binding protein 4, 59kDa; Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembl [...] (459 aa)
COL21A1collagen, type XXI, alpha 1 (957 aa)
RPA1replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing (616 aa)
DNAJB6DnaJ (Hsp40) homolog, subfamily B, member 6 (326 aa)
ITGA1integrin, alpha 1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen (1179 aa)
COL6A3collagen, type VI, alpha 3; Collagen VI acts as a cell-binding protein (3177 aa)
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix (1181 aa)
COL1A2collagen, type I, alpha 2 (1366 aa)
COL14A1collagen, type XIV, alpha 1 (1796 aa)
COL6A2collagen, type VI, alpha 2 (1019 aa)
ENSG00000170276Heat shock protein beta-2 (182 aa)
COL22A1collagen, type XXII, alpha 1; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts (1626 aa)
COL8A2collagen, type VIII, alpha 2; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity) (703 aa)
COL4A5collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa)
COL18A1collagen, type XVIII, alpha 1 (1519 aa)
COL27A1collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
COL20A1collagen, type XX, alpha 1; Probable collagen protein (1284 aa)
COL6A1collagen, type VI, alpha 1; Collagen VI acts as a cell-binding protein (1028 aa)
COL11A1collagen, type XI, alpha 1 (1806 aa)
COL4A6collagen, type IV, alpha 6 (1691 aa)
RPA2replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage (270 aa)
COL15A1collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa)
COL2A1collagen, type II, alpha 1 (1487 aa)
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (1670 aa)
COL4A4collagen, type IV, alpha 4; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1690 aa)
COL25A1collagen, type XXV, alpha 1; Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (654 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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