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NEDD8-MDP1 NEDD8-MDP1 PFDN4 PFDN4 SDF2L1 SDF2L1 NRIP3 NRIP3 NEDD8 NEDD8 SDF2 SDF2 DDI1 DDI1 DAG1 DAG1 DDI2 DDI2 EIF2B3 EIF2B3 POMT1 POMT1 NRIP2 NRIP2 POMT2 POMT2 DPM3 DPM3 DOLK DOLK CWH43 CWH43 PIGV PIGV GMPPB GMPPB DPM2 DPM2 GMPPA GMPPA ARFGAP1 ARFGAP1 MOGS MOGS GANAB GANAB GANC GANC TUSC3 TUSC3 TMED10 TMED10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
PIGVphosphatidylinositol glycan anchor biosynthesis, class V; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (493 aa)
TUSC3tumor suppressor candidate 3; Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase (348 aa)
CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae); Involved in lipid remodeling during GPI-anchor maturation (By similarity) (699 aa)
MOGSmannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner (837 aa)
SDF2stromal cell-derived factor 2 (211 aa)
SDF2L1stromal cell-derived factor 2-like 1 (221 aa)
NEDD8neural precursor cell expressed, developmentally down-regulated 8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (81 aa)
POMT2protein-O-mannosyltransferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (750 aa)
DDI1DNA-damage inducible 1 homolog 1 (S. cerevisiae) (396 aa)
TMED10transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] (219 aa)
GMPPBGDP-mannose pyrophosphorylase B (387 aa)
NRIP3nuclear receptor interacting protein 3 (241 aa)
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization (895 aa)
ARFGAP1ADP-ribosylation factor GTPase activating protein 1 (414 aa)
GMPPAGDP-mannose pyrophosphorylase A (420 aa)
DPM2dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit; Regulates the biosynthesis of dolichol phosphate- mannose. Essential for the ER localization and stable expression of DPM1 (84 aa)
GANCglucosidase, alpha; neutral C; Has alpha-glucosidase activity (914 aa)
NRIP2nuclear receptor interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2 (By similarity) (281 aa)
GANABglucosidase, alpha; neutral AB; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (966 aa)
EIF2B3eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP (452 aa)
DPM3dolichyl-phosphate mannosyltransferase polypeptide 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex (122 aa)
PFDN4prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (134 aa)
POMT1protein-O-mannosyltransferase 1 (747 aa)
DOLKdolichol kinase; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors (By similarity) (538 aa)
DDI2DNA-damage inducible 1 homolog 2 (S. cerevisiae) (399 aa)
NEDD8-MDP1NEDD8-MDP1 readthrough (170 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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