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MFAP4 MFAP4 FOXA1 FOXA1 DMBT1 DMBT1 SFTPA2 SFTPA2 CKAP4 CKAP4 SFTPA1 SFTPA1 SFTPB SFTPB CSF2RB CSF2RB SFTPD SFTPD SFTPC SFTPC CEBPB CEBPB CSF2RA CSF2RA RB1 RB1 MASP1 MASP1 CEBPD CEBPD CEBPA CEBPA ADORA2B ADORA2B ADORA2A ADORA2A DCN DCN SFTA3 SFTA3 DNAJC2 DNAJC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
DCNdecorin; May affect the rate of fibrils formation (359 aa)
FOXA1forkhead box A1; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a ’pioneer’ factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5’-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3’ (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-spe [...] (472 aa)
RB1retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] (928 aa)
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (728 aa)
ADORA2Badenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (332 aa)
CEBPBCCAAT/enhancer binding protein (C/EBP), beta; Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5’-T[TG]NNGNAA[TG]-3’. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proli [...] (345 aa)
SFTPCsurfactant protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces (197 aa)
ADORA2Aadenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (412 aa)
DMBT1deleted in malignant brain tumors 1 (2413 aa)
SFTPDsurfactant protein D; Contributes to the lung’s defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties (375 aa)
SFTPA2surfactant protein A2 (248 aa)
CKAP4cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF (602 aa)
DNAJC2DnaJ (Hsp40) homolog, subfamily C, member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruit [...] (621 aa)
SFTPBsurfactant protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter (393 aa)
MFAP4microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions (279 aa)
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor (897 aa)
CEBPDCCAAT/enhancer binding protein (C/EBP), delta; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages (269 aa)
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) (434 aa)
SFTPA1surfactant protein A1 (263 aa)
CEBPACCAAT/enhancer binding protein (C/EBP), alpha; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (358 aa)
SFTA3surfactant associated 3 (94 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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