node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CANX | GOLGA2 | ENSP00000247461 | ENSP00000416097 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | 0.533 |
CANX | LMAN1 | ENSP00000247461 | ENSP00000251047 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | lectin, mannose-binding, 1 | 0.890 |
CANX | UBC | ENSP00000247461 | ENSP00000344818 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | ubiquitin C | 0.987 |
CANX | YIPF3 | ENSP00000247461 | ENSP00000361499 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | Yip1 domain family, member 3; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis | 0.566 |
GOLGA2 | CANX | ENSP00000416097 | ENSP00000247461 | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.533 |
GOLGA2 | GORASP1 | ENSP00000416097 | ENSP00000313869 | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes | 0.999 |
GOLGA2 | LMAN1 | ENSP00000416097 | ENSP00000251047 | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | lectin, mannose-binding, 1 | 0.522 |
GOLGA2 | UBC | ENSP00000416097 | ENSP00000344818 | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | ubiquitin C | 0.730 |
GOLGA2 | YIPF3 | ENSP00000416097 | ENSP00000361499 | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | Yip1 domain family, member 3; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis | 0.566 |
GORASP1 | GOLGA2 | ENSP00000313869 | ENSP00000416097 | golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | 0.999 |
GORASP1 | LMAN1 | ENSP00000313869 | ENSP00000251047 | golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes | lectin, mannose-binding, 1 | 0.581 |
GORASP1 | YIPF3 | ENSP00000313869 | ENSP00000361499 | golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes | Yip1 domain family, member 3; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis | 0.566 |
KRTAP10-8 | KRTAP5-9 | ENSP00000335565 | ENSP00000431443 | keratin associated protein 10-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | keratin associated protein 5-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.487 |
KRTAP5-9 | KRTAP10-8 | ENSP00000431443 | ENSP00000335565 | keratin associated protein 5-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | keratin associated protein 10-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins | 0.487 |
LMAN1 | CANX | ENSP00000251047 | ENSP00000247461 | lectin, mannose-binding, 1 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.890 |
LMAN1 | GOLGA2 | ENSP00000251047 | ENSP00000416097 | lectin, mannose-binding, 1 | golgin A2; Golgi auto-antigen; probably involved in maintaining cis-Golgi structure | 0.522 |
LMAN1 | GORASP1 | ENSP00000251047 | ENSP00000313869 | lectin, mannose-binding, 1 | golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes | 0.581 |
LMAN1 | UBC | ENSP00000251047 | ENSP00000344818 | lectin, mannose-binding, 1 | ubiquitin C | 0.950 |
LMAN1 | YIPF3 | ENSP00000251047 | ENSP00000361499 | lectin, mannose-binding, 1 | Yip1 domain family, member 3; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis | 0.566 |
PLSCR1 | UBC | ENSP00000345494 | ENSP00000344818 | phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | ubiquitin C | 0.854 |