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REXO1 | REX1, RNA exonuclease 1 homolog (S. cerevisiae); Seems to have no detectable effect on transcription elongation in vitro (1221 aa) | |||
DAO | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids (347 aa) | |||
AGXT2 | alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (514 aa) | |||
LOC81691 | Putative RNA exonuclease NEF-sp (774 aa) | |||
TARBP2 | TAR (HIV-1) RNA binding protein 2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interferin [...] (366 aa) | |||
AGXT | alanine-glyoxylate aminotransferase (392 aa) | |||
GRHPR | glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (328 aa) | |||
PRKRA | protein kinase, interferon-inducible double stranded RNA dependent activator; Activates EIF2AK2/PKR in the absence of double stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ’Lys-386’ at ’Ser-392’ respectively and enhances its activity in [...] (313 aa) | |||
CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells (475 aa) | |||
AEN | apoptosis enhancing nuclease; Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (325 aa) | |||
TEX11 | testis expressed 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) (940 aa) | |||
UBC | ubiquitin C (685 aa) | |||
PM20D1 | peptidase M20 domain containing 1 (502 aa) | |||
SRSF11 | serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing (484 aa) | |||
HYI | hydroxypyruvate isomerase (putative); Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) (277 aa) | |||
REXO1L1 | REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1 (675 aa) | |||
TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5’-GCCNNNGGC-3’ and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis [...] (437 aa) | |||
SHBG | sex hormone-binding globulin (402 aa) | |||
ACY1 | aminoacylase 1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) (408 aa) | |||
REXO1L11P | REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 11, pseudogene (675 aa) | |||
OAZ3 | ornithine decarboxylase antizyme 3; Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells (203 aa) | |||
ENSG00000114786 | ABHD14A-ACY1 readthrough (non-protein coding) (509 aa) | |||
REXO1L10P | REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 10, pseudogene (675 aa) | |||
OAZ2 | ornithine decarboxylase antizyme 2; Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration (By similarity) (189 aa) | |||
OAZ1 | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (235 aa) |