node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C9orf78 | FKBP9 | ENSP00000361524 | ENSP00000242209 | chromosome 9 open reading frame 78 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | 0.538 |
C9orf78 | H2AFV | ENSP00000361524 | ENSP00000308405 | chromosome 9 open reading frame 78 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.551 |
C9orf78 | HERC4 | ENSP00000361524 | ENSP00000378624 | chromosome 9 open reading frame 78 | HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) | 0.538 |
C9orf78 | HEXA | ENSP00000361524 | ENSP00000268097 | chromosome 9 open reading frame 78 | hexosaminidase A (alpha polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity | 0.538 |
C9orf78 | LIMD1 | ENSP00000361524 | ENSP00000273317 | chromosome 9 open reading frame 78 | LIM domains containing 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a t [...] | 0.538 |
C9orf78 | NUBP2 | ENSP00000361524 | ENSP00000262302 | chromosome 9 open reading frame 78 | nucleotide binding protein 2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity) | 0.538 |
C9orf78 | UBC | ENSP00000361524 | ENSP00000344818 | chromosome 9 open reading frame 78 | ubiquitin C | 0.483 |
C9orf78 | UBE2R2 | ENSP00000361524 | ENSP00000263228 | chromosome 9 open reading frame 78 | ubiquitin-conjugating enzyme E2R 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and ’Lys-48’-linked polyubiquitination. May be involved in degradation of katenin | 0.538 |
C9orf78 | UBR7 | ENSP00000361524 | ENSP00000013070 | chromosome 9 open reading frame 78 | ubiquitin protein ligase E3 component n-recognin 7 (putative); E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity) | 0.538 |
FKBP9 | C9orf78 | ENSP00000242209 | ENSP00000361524 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | chromosome 9 open reading frame 78 | 0.538 |
FKBP9 | H2AFV | ENSP00000242209 | ENSP00000308405 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | 0.547 |
FKBP9 | HERC4 | ENSP00000242209 | ENSP00000378624 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) | 0.546 |
FKBP9 | HEXA | ENSP00000242209 | ENSP00000268097 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | hexosaminidase A (alpha polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity | 0.472 |
FKBP9 | LIMD1 | ENSP00000242209 | ENSP00000273317 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | LIM domains containing 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a t [...] | 0.538 |
FKBP9 | NUBP2 | ENSP00000242209 | ENSP00000262302 | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | nucleotide binding protein 2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity) | 0.538 |
H2AFV | C9orf78 | ENSP00000308405 | ENSP00000361524 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | chromosome 9 open reading frame 78 | 0.551 |
H2AFV | FKBP9 | ENSP00000308405 | ENSP00000242209 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | FK506 binding protein 9, 63 kDa; PPIases accelerate the folding of proteins during protein synthesis | 0.547 |
H2AFV | HERC4 | ENSP00000308405 | ENSP00000378624 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | HECT and RLD domain containing E3 ubiquitin protein ligase 4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity) | 0.615 |
H2AFV | HEXA | ENSP00000308405 | ENSP00000268097 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | hexosaminidase A (alpha polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity | 0.538 |
H2AFV | NUBP2 | ENSP00000308405 | ENSP00000262302 | H2A histone family, member V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be [...] | nucleotide binding protein 2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity) | 0.538 |