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LHX4 LHX4 TLX1 TLX1 HLX HLX OTX2 OTX2 CRX CRX NKX1-2 NKX1-2 LDB1 LDB1 OTX1 OTX1 LDB2 LDB2 TLX3 TLX3 LHX3 LHX3 RFC2 RFC2 BARHL1 BARHL1 BARHL2 BARHL2 KRAS KRAS DBX2 DBX2 ESX1 ESX1 LBX1 LBX1 DBX1 DBX1 BARX1 BARX1 TLX2 TLX2 ARGFX ARGFX SRF SRF NKX1-1 NKX1-1 LBX2 LBX2 BARX2 BARX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RFC2replication factor C (activator 1) 2, 40kDa (354 aa)
CRXcone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (299 aa)
DBX1developing brain homeobox 1 (382 aa)
TLX2T-cell leukemia homeobox 2; Transcription activator that binds DNA elements with the consensus sequence 5’-CGGTAATTGG-3’. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract (By similarity) (284 aa)
BARX1BARX homeobox 1; Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity (By similarity). Binds to a regulatory module of the NCAM promoter (254 aa)
KRASv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
BARHL1BarH-like homeobox 1 (327 aa)
LHX4LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity) (390 aa)
SRFserum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation (508 aa)
BARX2BARX homeobox 2; Transcription factor. Binds optimally to the DNA consensus sequence 5’-YYTAATGRTTTTY-3’. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity) (279 aa)
OTX1orthodenticle homeobox 1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’ (354 aa)
TLX3T-cell leukemia homeobox 3 (291 aa)
LDB2LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors (373 aa)
DBX2developing brain homeobox 2 (339 aa)
ARGFXarginine-fifty homeobox; Putative transcription factor (By similarity) (315 aa)
OTX2orthodenticle homeobox 2; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’ (297 aa)
HLXH2.0-like homeobox; Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity) (488 aa)
LBX1ladybird homeobox 1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord (By similarity) (281 aa)
TLX1T-cell leukemia homeobox 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’ (330 aa)
BARHL2BarH-like homeobox 2; Potential regulator of neural basic helix-loop-helix genes (By similarity) (387 aa)
LHX3LIM homeobox 3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (402 aa)
ESX1ESX homeobox 1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover (406 aa)
LDB1LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) (411 aa)
NKX1-1NK1 homeobox 1 (411 aa)
LBX2ladybird homeobox 2; Putative transcription factor (By similarity) (194 aa)
NKX1-2NK1 homeobox 2; May function in cell specification, particularly in the CNS (By similarity) (332 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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