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DDX31 DDX31 DDX55 DDX55 RSL1D1 RSL1D1 PRPF31 PRPF31 SURF6 SURF6 CIRH1A CIRH1A PWP2 PWP2 NOC4L NOC4L RPF2 RPF2 ENSG00000248354 ENSG00000248354 UTP18 UTP18 COG2 COG2 MPHOSPH10 MPHOSPH10 BYSL BYSL RRP8 RRP8 NOP56 NOP56 CEP70 CEP70 UTP11L UTP11L UBC UBC NOP58 NOP58 LARP1B LARP1B FTSJ2 FTSJ2 CNBP CNBP SUMO2 SUMO2 EXOSC10 EXOSC10 LARP1 LARP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UTP18UTP18 small subunit (SSU) processome component homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (556 aa)
BYSLbystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa)
DDX55DEAD (Asp-Glu-Ala-Asp) box polypeptide 55; Probable ATP-binding RNA helicase (600 aa)
FTSJ2FtsJ RNA methyltransferase homolog 2 (E. coli); Probable methyltransferase (246 aa)
MPHOSPH10M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
RRP8ribosomal RNA processing 8, methyltransferase, homolog (yeast); Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell- upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at ’Lys- 9’ (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, [...] (456 aa)
NOP58NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa)
CEP70centrosomal protein 70kDa (597 aa)
PWP2PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
LARP1BLa ribonucleoprotein domain family, member 1B (914 aa)
PRPF31PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) (499 aa)
CIRH1Acirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa)
NOC4Lnucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
LARP1La ribonucleoprotein domain family, member 1 (1019 aa)
UBCubiquitin C (685 aa)
COG2component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa)
SURF6surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) (361 aa)
DDX31DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 (851 aa)
UTP11LUTP11-like, U3 small nucleolar ribonucleoprotein, (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (253 aa)
EXOSC10exosome component 10; Putative catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] (885 aa)
NOP56NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa)
RPF2ribosome production factor 2 homolog (S. cerevisiae) (306 aa)
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] (95 aa)
CNBPCCHC-type zinc finger, nucleic acid binding protein (179 aa)
ENSG00000248354Uncharacterized protein (205 aa)
RSL1D1ribosomal L1 domain containing 1 (490 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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