node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC1 | MCU | ENSP00000382342 | ENSP00000362144 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.644 |
ABCC1 | UBC | ENSP00000382342 | ENSP00000344818 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ubiquitin C | 0.954 |
C22orf32 | CCDC109B | ENSP00000327467 | ENSP00000378145 | chromosome 22 open reading frame 32 | coiled-coil domain containing 109B | 0.959 |
C22orf32 | EFHA1 | ENSP00000327467 | ENSP00000371811 | chromosome 22 open reading frame 32 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.939 |
C22orf32 | MCU | ENSP00000327467 | ENSP00000362144 | chromosome 22 open reading frame 32 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.936 |
C22orf32 | MICU1 | ENSP00000327467 | ENSP00000354415 | chromosome 22 open reading frame 32 | mitochondrial calcium uptake 1 | 0.958 |
CCDC109B | C22orf32 | ENSP00000378145 | ENSP00000327467 | coiled-coil domain containing 109B | chromosome 22 open reading frame 32 | 0.959 |
CCDC109B | EFHA1 | ENSP00000378145 | ENSP00000371811 | coiled-coil domain containing 109B | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.938 |
CCDC109B | MCU | ENSP00000378145 | ENSP00000362144 | coiled-coil domain containing 109B | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.911 |
CCDC109B | MICU1 | ENSP00000378145 | ENSP00000354415 | coiled-coil domain containing 109B | mitochondrial calcium uptake 1 | 0.949 |
EFHA1 | C22orf32 | ENSP00000371811 | ENSP00000327467 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | chromosome 22 open reading frame 32 | 0.939 |
EFHA1 | CCDC109B | ENSP00000371811 | ENSP00000378145 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | coiled-coil domain containing 109B | 0.938 |
EFHA1 | MCU | ENSP00000371811 | ENSP00000362144 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.973 |
EFHA1 | MICU1 | ENSP00000371811 | ENSP00000354415 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | mitochondrial calcium uptake 1 | 0.923 |
EFHA1 | UBC | ENSP00000371811 | ENSP00000344818 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | ubiquitin C | 0.721 |
ELAVL1 | UBC | ENSP00000385269 | ENSP00000344818 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro | ubiquitin C | 0.998 |
ERLIN2 | MCU | ENSP00000276461 | ENSP00000362144 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.644 |
ERLIN2 | UBC | ENSP00000276461 | ENSP00000344818 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | ubiquitin C | 0.919 |
ICT1 | UBC | ENSP00000301585 | ENSP00000344818 | immature colon carcinoma transcript 1; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes | ubiquitin C | 0.532 |
MCU | ABCC1 | ENSP00000362144 | ENSP00000382342 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.644 |