node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DUSP1 | PTEN | ENSP00000239223 | ENSP00000361021 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.472 |
DUSP1 | UBC | ENSP00000239223 | ENSP00000344818 | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | ubiquitin C | 0.991 |
DUSP12 | UBC | ENSP00000356920 | ENSP00000344818 | dual specificity phosphatase 12 | ubiquitin C | 0.422 |
PTEN | DUSP1 | ENSP00000361021 | ENSP00000239223 | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | 0.472 |
PTEN | UBC | ENSP00000361021 | ENSP00000344818 | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | ubiquitin C | 0.999 |
SLC25A22 | UBC | ENSP00000322020 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier- glutamate), member 22 | ubiquitin C | 0.520 |
SLC25A25 | SLC25A4 | ENSP00000362159 | ENSP00000281456 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane | 0.412 |
SLC25A25 | SLC25A5 | ENSP00000362159 | ENSP00000360671 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | 0.401 |
SLC25A25 | UBC | ENSP00000362159 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | ubiquitin C | 0.620 |
SLC25A31 | UBC | ENSP00000281154 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility | ubiquitin C | 0.807 |
SLC25A4 | SLC25A25 | ENSP00000281456 | ENSP00000362159 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | 0.412 |
SLC25A4 | UBC | ENSP00000281456 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane | ubiquitin C | 0.972 |
SLC25A5 | SLC25A25 | ENSP00000360671 | ENSP00000362159 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | 0.401 |
SLC25A5 | SURF1 | ENSP00000360671 | ENSP00000361042 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | surfeit 1; Probably involved in the biogenesis of the COX complex | 0.409 |
SLC25A5 | UBC | ENSP00000360671 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | ubiquitin C | 0.995 |
SLC25A6 | UBC | ENSP00000370808 | ENSP00000344818 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis | ubiquitin C | 0.985 |
SURF1 | SLC25A5 | ENSP00000361042 | ENSP00000360671 | surfeit 1; Probably involved in the biogenesis of the COX complex | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | 0.409 |
UBC | DUSP1 | ENSP00000344818 | ENSP00000239223 | ubiquitin C | dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both ’Thr-183’ and ’Tyr-185’, regulating its activity during the meiotic cell cycle (By similarity) | 0.991 |
UBC | DUSP12 | ENSP00000344818 | ENSP00000356920 | ubiquitin C | dual specificity phosphatase 12 | 0.422 |
UBC | PTEN | ENSP00000344818 | ENSP00000361021 | ubiquitin C | phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.999 |