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RABAC1 | Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity) (185 aa) | |||
HOXA5 | homeobox A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5’-CYYNATTA[TG]Y-3’ (270 aa) | |||
IRX4 | iroquois homeobox 4; Likely to be an important mediator of ventricular differentiation during cardiac development (519 aa) | |||
HOXB8 | homeobox B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (243 aa) | |||
HOXB5 | homeobox B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (269 aa) | |||
MEIS1 | Meis homeobox 1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias (390 aa) | |||
IRX6 | iroquois homeobox 6 (446 aa) | |||
PKNOX1 | PBX/knotted 1 homeobox 1 (436 aa) | |||
PKNOX2 | PBX/knotted 1 homeobox 2 (472 aa) | |||
TRIM44 | tripartite motif containing 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (344 aa) | |||
IRX1 | iroquois homeobox 1 (480 aa) | |||
HOXC4 | homeobox C4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (264 aa) | |||
IRX2 | iroquois homeobox 2 (471 aa) | |||
TGIF2LY | TGFB-induced factor homeobox 2-like, Y-linked; May have a transcription role in testis. May act as a competitor/regulator of TGIF2LX (185 aa) | |||
AGTRAP | angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity (159 aa) | |||
TGIF1 | TGFB-induced factor homeobox 1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha [...] (401 aa) | |||
IRX3 | iroquois homeobox 3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity) (501 aa) | |||
HOXA1 | homeobox A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (335 aa) | |||
HOXA9 | homeobox A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (272 aa) | |||
HOXA4 | homeobox A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5’-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5’-TAATGA[CG]-3’ and 5’-CTAATTTT- 3’ (320 aa) | |||
MAGEC2 | melanoma antigen family C, 2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex (373 aa) | |||
TGIF2LX | TGFB-induced factor homeobox 2-like, X-linked; May have a transcription role in testis (241 aa) | |||
TLX1 | T-cell leukemia homeobox 1; Controls the genesis of the spleen. Binds to the DNA sequence 5’-GGCGGTAAGTGG-3’ (330 aa) | |||
PBX3 | pre-B-cell leukemia homeobox 3; Transcriptional activator that binds the sequence 5’- ATCAATCAA-3’ (434 aa) | |||
MEIS3 | Meis homeobox 3 (421 aa) | |||
MEIS2 | Meis homeobox 2 (477 aa) |