| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABCB7 | MTCH1 | ENSP00000253577 | ENSP00000362718 | ATP-binding cassette, sub-family B (MDR/TAP), member 7; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins | mitochondrial carrier 1 | 0.644 |
| ABCB7 | UBC | ENSP00000253577 | ENSP00000344818 | ATP-binding cassette, sub-family B (MDR/TAP), member 7; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins | ubiquitin C | 0.650 |
| EWSR1 | MTCH1 | ENSP00000400142 | ENSP00000362718 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | mitochondrial carrier 1 | 0.645 |
| EWSR1 | UBC | ENSP00000400142 | ENSP00000344818 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | ubiquitin C | 0.929 |
| FGFR1OP2 | MTCH1 | ENSP00000229395 | ENSP00000362718 | FGFR1 oncogene partner 2; May be involved in wound healing pathway (By similarity) | mitochondrial carrier 1 | 0.644 |
| FGFR1OP2 | UBC | ENSP00000229395 | ENSP00000344818 | FGFR1 oncogene partner 2; May be involved in wound healing pathway (By similarity) | ubiquitin C | 0.516 |
| HNRNPU | MTCH1 | ENSP00000283179 | ENSP00000362718 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | mitochondrial carrier 1 | 0.644 |
| HNRNPU | UBC | ENSP00000283179 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | ubiquitin C | 0.995 |
| LAMTOR3 | MTCH1 | ENSP00000424183 | ENSP00000362718 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | mitochondrial carrier 1 | 0.644 |
| LAMTOR3 | UBC | ENSP00000424183 | ENSP00000344818 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | ubiquitin C | 0.483 |
| MTCH1 | ABCB7 | ENSP00000362718 | ENSP00000253577 | mitochondrial carrier 1 | ATP-binding cassette, sub-family B (MDR/TAP), member 7; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins | 0.644 |
| MTCH1 | EWSR1 | ENSP00000362718 | ENSP00000400142 | mitochondrial carrier 1 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | 0.645 |
| MTCH1 | FGFR1OP2 | ENSP00000362718 | ENSP00000229395 | mitochondrial carrier 1 | FGFR1 oncogene partner 2; May be involved in wound healing pathway (By similarity) | 0.644 |
| MTCH1 | HNRNPU | ENSP00000362718 | ENSP00000283179 | mitochondrial carrier 1 | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA | 0.644 |
| MTCH1 | LAMTOR3 | ENSP00000362718 | ENSP00000424183 | mitochondrial carrier 1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] | 0.644 |
| MTCH1 | PSEN1 | ENSP00000362718 | ENSP00000326366 | mitochondrial carrier 1 | presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin [...] | 0.982 |
| MTCH1 | UBC | ENSP00000362718 | ENSP00000344818 | mitochondrial carrier 1 | ubiquitin C | 0.624 |
| PSEN1 | MTCH1 | ENSP00000326366 | ENSP00000362718 | presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin [...] | mitochondrial carrier 1 | 0.982 |
| PSEN1 | UBC | ENSP00000326366 | ENSP00000344818 | presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin [...] | ubiquitin C | 0.977 |
| SMAD2 | UBC | ENSP00000262160 | ENSP00000344818 | SMAD family member 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator | ubiquitin C | 0.999 |
Share
