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STRINGSTRING
PLK1 PLK1 NUP62 NUP62 NR4A1 NR4A1 UBC UBC VPS28 VPS28 KIAA1598 KIAA1598 ITGA5 ITGA5 ITGA2 ITGA2 ITGB4 ITGB4 FABP3 FABP3 ITGB1 ITGB1 TNNI3K TNNI3K ITGA1 ITGA1 CARK CARK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ITGB4integrin, beta 4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility (1822 aa)
ITGA1integrin, alpha 1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen (1179 aa)
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions (1049 aa)
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix (1181 aa)
PLK1polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] (603 aa)
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (798 aa)
NUP62nucleoporin 62kDa; Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex (522 aa)
UBCubiquitin C (685 aa)
KIAA1598KIAA1598 (631 aa)
NR4A1nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 (611 aa)
TNNI3KTNNI3 interacting kinase; May play a role in cardiac physiology (936 aa)
FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters (133 aa)
VPS28vacuolar protein sorting 28 homolog (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process (233 aa)
CARKFPGT-TNNI3K readthrough; May play a role in cardiac physiology (936 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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