| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DACH1 | EYA3 | ENSP00000304994 | ENSP00000362978 | dachshund homolog 1 (Drosophila) | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | 0.786 |
| DACH1 | SIX1 | ENSP00000304994 | ENSP00000247182 | dachshund homolog 1 (Drosophila) | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | 0.994 |
| DACH1 | SIX2 | ENSP00000304994 | ENSP00000304502 | dachshund homolog 1 (Drosophila) | SIX homeobox 2; May be involved in limb tendon and ligament development (By similarity) | 0.853 |
| DACH1 | SIX4 | ENSP00000304994 | ENSP00000216513 | dachshund homolog 1 (Drosophila) | SIX homeobox 4 | 0.789 |
| DACH1 | SIX5 | ENSP00000304994 | ENSP00000316842 | dachshund homolog 1 (Drosophila) | SIX homeobox 5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5’-GGTGTCAG-3’ motif present in the ARE regulatory element of ATP1A1. Binds a 5’- TCA[AG][AG]TTNC-3’ motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity) | 0.760 |
| EYA3 | DACH1 | ENSP00000362978 | ENSP00000304994 | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | dachshund homolog 1 (Drosophila) | 0.786 |
| EYA3 | H2AFX | ENSP00000362978 | ENSP00000364310 | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | 0.673 |
| EYA3 | SIX1 | ENSP00000362978 | ENSP00000247182 | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | 0.852 |
| EYA3 | SIX2 | ENSP00000362978 | ENSP00000304502 | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | SIX homeobox 2; May be involved in limb tendon and ligament development (By similarity) | 0.812 |
| EYA3 | SIX4 | ENSP00000362978 | ENSP00000216513 | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | SIX homeobox 4 | 0.777 |
| EYA3 | SIX5 | ENSP00000362978 | ENSP00000316842 | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | SIX homeobox 5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5’-GGTGTCAG-3’ motif present in the ARE regulatory element of ATP1A1. Binds a 5’- TCA[AG][AG]TTNC-3’ motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity) | 0.776 |
| EYA3 | SKI | ENSP00000362978 | ENSP00000367797 | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | v-ski sarcoma viral oncogene homolog (avian); May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling | 0.576 |
| H2AFX | EYA3 | ENSP00000364310 | ENSP00000362978 | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | 0.673 |
| H2AFX | UBC | ENSP00000364310 | ENSP00000344818 | H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in resp [...] | ubiquitin C | 0.999 |
| SIX1 | DACH1 | ENSP00000247182 | ENSP00000304994 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | dachshund homolog 1 (Drosophila) | 0.994 |
| SIX1 | EYA3 | ENSP00000247182 | ENSP00000362978 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | 0.852 |
| SIX1 | SKI | ENSP00000247182 | ENSP00000367797 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | v-ski sarcoma viral oncogene homolog (avian); May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling | 0.576 |
| SIX1 | UBC | ENSP00000247182 | ENSP00000344818 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | ubiquitin C | 0.585 |
| SIX2 | DACH1 | ENSP00000304502 | ENSP00000304994 | SIX homeobox 2; May be involved in limb tendon and ligament development (By similarity) | dachshund homolog 1 (Drosophila) | 0.853 |
| SIX2 | EYA3 | ENSP00000304502 | ENSP00000362978 | SIX homeobox 2; May be involved in limb tendon and ligament development (By similarity) | eyes absent homolog 3 (Drosophila); Tyrosine phosphatase that specifically dephosphorylates ’Tyr-142’ of histone H2AX (H2AXY142ph). ’Tyr-142’ phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, [...] | 0.812 |
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