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ZDHHC14 ZDHHC14 STX7 STX7 ZDHHC19 ZDHHC19 ZDHHC11 ZDHHC11 ERBB3 ERBB3 ZDHHC5 ZDHHC5 ZDHHC7 ZDHHC7 ZDHHC9 ZDHHC9 ZDHHC12 ZDHHC12 RHBDD2 RHBDD2 ZDHHC22 ZDHHC22 ZDHHC21 ZDHHC21 SLC31A1 SLC31A1 CCS CCS ZDHHC23 ZDHHC23 ZDHHC3 ZDHHC3 RHBDD3 RHBDD3 ZDHHC8 ZDHHC8 ZDHHC24 ZDHHC24 ZDHHC1 ZDHHC1 RHBDD1 RHBDD1 ZDHHC18 ZDHHC18 ZDHHC11B ZDHHC11B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RHBDD2rhomboid domain containing 2 (364 aa)
RHBDD3rhomboid domain containing 3 (386 aa)
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by neuregulins and NTAK (1342 aa)
ZDHHC11zinc finger, DHHC-type containing 11 (412 aa)
ZDHHC5zinc finger, DHHC-type containing 5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity) (715 aa)
ZDHHC3zinc finger, DHHC-type containing 3; Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi (By similarity) (327 aa)
ZDHHC19zinc finger, DHHC-type containing 19 (309 aa)
ZDHHC24zinc finger, DHHC-type containing 24 (284 aa)
ZDHHC22zinc finger, DHHC-type containing 22 (263 aa)
ZDHHC23zinc finger, DHHC-type containing 23; May be involved in NOS1 regulation and targeting to the synaptic membrane (By similarity) (409 aa)
ZDHHC1zinc finger, DHHC-type containing 1 (485 aa)
ZDHHC7zinc finger, DHHC-type containing 7; Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear re [...] (345 aa)
RHBDD1rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...] (315 aa)
ZDHHC9zinc finger, DHHC-type containing 9 (364 aa)
ZDHHC14zinc finger, DHHC-type containing 14 (488 aa)
STX7syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (261 aa)
ZDHHC12zinc finger, DHHC-type containing 12 (267 aa)
ZDHHC18zinc finger, DHHC-type containing 18; Has palmitoyltransferase activity towards HRAS and LCK (By similarity) (388 aa)
SLC31A1solute carrier family 31 (copper transporters), member 1; High-affinity, saturable copper transporter involved in dietary copper uptake (190 aa)
ZDHHC21zinc finger, DHHC-type containing 21; Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity) (265 aa)
ZDHHC8zinc finger, DHHC-type containing 8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1 (778 aa)
CCScopper chaperone for superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (274 aa)
ZDHHC11Bzinc finger, DHHC-type containing 11B (382 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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