8 items (Homo sapiens) - STRING network view

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	EXTL3	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity) (919 aa)
	NDST1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that [...] (882 aa)
	NDST4	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity) (872 aa)
	NDST3	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity (873 aa)
	SDR16C5	short chain dehydrogenase/reductase family 16C, member 5; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH (309 aa)
	NDST2	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate (883 aa)
	GRB2	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (217 aa)
	EXTL1	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity) (676 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EXTL1	EXTL3	ENSP00000363398	ENSP00000220562	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	0.539
EXTL1	NDST1	ENSP00000363398	ENSP00000261797	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that [...]	0.808
EXTL1	NDST2	ENSP00000363398	ENSP00000310657	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate	0.790
EXTL1	NDST3	ENSP00000363398	ENSP00000296499	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity	0.798
EXTL1	NDST4	ENSP00000363398	ENSP00000264363	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity)	0.764
EXTL3	EXTL1	ENSP00000220562	ENSP00000363398	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	0.539
EXTL3	NDST1	ENSP00000220562	ENSP00000261797	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that [...]	0.641
EXTL3	NDST2	ENSP00000220562	ENSP00000310657	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate	0.595
EXTL3	NDST3	ENSP00000220562	ENSP00000296499	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity	0.535
EXTL3	NDST4	ENSP00000220562	ENSP00000264363	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity)	0.540
NDST1	EXTL1	ENSP00000261797	ENSP00000363398	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that [...]	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	0.808
NDST1	EXTL3	ENSP00000261797	ENSP00000220562	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that [...]	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	0.641
NDST1	NDST2	ENSP00000261797	ENSP00000310657	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that [...]	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate	0.901
NDST2	EXTL1	ENSP00000310657	ENSP00000363398	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	0.790
NDST2	EXTL3	ENSP00000310657	ENSP00000220562	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	0.595
NDST2	NDST1	ENSP00000310657	ENSP00000261797	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that [...]	0.901
NDST3	EXTL1	ENSP00000296499	ENSP00000363398	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	0.798
NDST3	EXTL3	ENSP00000296499	ENSP00000220562	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	0.535
NDST4	EXTL1	ENSP00000264363	ENSP00000363398	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity)	exostoses (multiple)-like 1; Probable glycosyltransferase (By similarity)	0.764
NDST4	EXTL3	ENSP00000264363	ENSP00000220562	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity)	exostoses (multiple)-like 3; Probable glycosyltransferase (By similarity)	0.540

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