26 items (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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	OXCT1	3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) (520 aa)
	ASS1	argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) (412 aa)
	ACLY	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
	KAT7	K(lysine) acetyltransferase 7; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription (611 aa)
	KIAA0368	KIAA0368; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolyis (2017 aa)
	KAT6A	K(lysine) acetyltransferase 6A; Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at ’Lys-120’ and ’Lys-382’ and controls its transcriptional activity via association with PML (2004 aa)
	ACAT1	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
	ACAA2	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
	BDH2	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity) (245 aa)
	MS4A7	membrane-spanning 4-domains, subfamily A, member 7; May be involved in signal transduction as a component of a multimeric receptor complex (240 aa)
	MS4A8B	membrane-spanning 4-domains, subfamily A, member 8B; May be involved in signal transduction as a component of a multimeric receptor complex (250 aa)
	ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1; May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (203 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (520 aa)
	AACS	acetoacetyl-CoA synthetase (672 aa)
	HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit (474 aa)
	ACAA1	acetyl-CoA acyltransferase 1 (424 aa)
	DLST	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components- 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (453 aa)
	CS	citrate synthase (466 aa)
	BDH1	3-hydroxybutyrate dehydrogenase, type 1 (343 aa)
	ACAT2	acetyl-CoA acetyltransferase 2 (397 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (508 aa)
	OXCT2	3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) (517 aa)
	HMGCL	3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism (325 aa)
	AUH	AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs (339 aa)
	DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1; Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria (397 aa)
	PEX5	peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import (654 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AACS	ACAA1	ENSP00000324842	ENSP00000333664	acetoacetyl-CoA synthetase	acetyl-CoA acyltransferase 1	0.405
AACS	ACAA2	ENSP00000324842	ENSP00000285093	acetoacetyl-CoA synthetase	acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage	0.442
AACS	ACAT1	ENSP00000324842	ENSP00000265838	acetoacetyl-CoA synthetase	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.941
AACS	ACAT2	ENSP00000324842	ENSP00000356015	acetoacetyl-CoA synthetase	acetyl-CoA acetyltransferase 2	0.941
AACS	ACLY	ENSP00000324842	ENSP00000253792	acetoacetyl-CoA synthetase	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.931
AACS	BDH1	ENSP00000324842	ENSP00000350914	acetoacetyl-CoA synthetase	3-hydroxybutyrate dehydrogenase, type 1	0.928
AACS	BDH2	ENSP00000324842	ENSP00000296424	acetoacetyl-CoA synthetase	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)	0.911
AACS	CS	ENSP00000324842	ENSP00000342056	acetoacetyl-CoA synthetase	citrate synthase	0.573
AACS	HMGCL	ENSP00000324842	ENSP00000363614	acetoacetyl-CoA synthetase	3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism	0.929
AACS	HMGCS1	ENSP00000324842	ENSP00000322706	acetoacetyl-CoA synthetase	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.942
AACS	HMGCS2	ENSP00000324842	ENSP00000358414	acetoacetyl-CoA synthetase	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase	0.934
AACS	OXCT1	ENSP00000324842	ENSP00000196371	acetoacetyl-CoA synthetase	3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.886
AACS	OXCT2	ENSP00000324842	ENSP00000361914	acetoacetyl-CoA synthetase	3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)	0.832
ACAA1	AACS	ENSP00000333664	ENSP00000324842	acetyl-CoA acyltransferase 1	acetoacetyl-CoA synthetase	0.405
ACAA1	ACAT1	ENSP00000333664	ENSP00000265838	acetyl-CoA acyltransferase 1	acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism	0.924
ACAA1	ACAT2	ENSP00000333664	ENSP00000356015	acetyl-CoA acyltransferase 1	acetyl-CoA acetyltransferase 2	0.911
ACAA1	ACLY	ENSP00000333664	ENSP00000253792	acetyl-CoA acyltransferase 1	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.755
ACAA1	AUH	ENSP00000333664	ENSP00000364883	acetyl-CoA acyltransferase 1	AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs	0.753
ACAA1	BDH2	ENSP00000333664	ENSP00000296424	acetyl-CoA acyltransferase 1	3-hydroxybutyrate dehydrogenase, type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron homeostasis and transport. Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity)	0.467
ACAA1	CS	ENSP00000333664	ENSP00000342056	acetyl-CoA acyltransferase 1	citrate synthase	0.869

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