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NAIP NAIP ACOT9 ACOT9 ACOT7 ACOT7 PCYT1B PCYT1B PCYT1A PCYT1A HIBCH HIBCH BIRC3 BIRC3 XIAP XIAP ACOT11 ACOT11 SORBS3 SORBS3 BIRC2 BIRC2 PIK3R1 PIK3R1 BIRC5 BIRC5 BIRC8 BIRC8 ENSG00000263020 ENSG00000263020 BIRC7 BIRC7 KXD1 KXD1 DGCR6 DGCR6 BIRC6 BIRC6 RNF220 RNF220 ACOT12 ACOT12 ZNF490 ZNF490 ZC4H2 ZC4H2 ZNF524 ZNF524 PCYT2 PCYT2 ZNF223 ZNF223
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
BIRC7baculoviral IAP repeat containing 7; Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the a [...] (298 aa)
KXD1KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) (176 aa)
BIRC2baculoviral IAP repeat containing 2; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions- acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for it [...] (618 aa)
SORBS3sorbin and SH3 domain containing 3; Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain (671 aa)
BIRC3baculoviral IAP repeat containing 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions- acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its [...] (604 aa)
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (724 aa)
PCYT1Aphosphate cytidylyltransferase 1, choline, alpha; Controls phosphatidylcholine synthesis (367 aa)
ZNF524zinc finger protein 524; May be involved in transcriptional regulation (264 aa)
BIRC5baculoviral IAP repeat containing 5 (165 aa)
ACOT12acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA (555 aa)
ZNF490zinc finger protein 490; May be involved in transcriptional regulation (529 aa)
DGCR6DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches (220 aa)
RNF220ring finger protein 220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity) (566 aa)
XIAPX-linked inhibitor of apoptosis; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase [...] (497 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (386 aa)
ACOT11acyl-CoA thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (607 aa)
ZC4H2zinc finger, C4H2 domain containing (224 aa)
ENSG00000263020Lymphocyte antigen 6 complex, locus G5B (228 aa)
ACOT7acyl-CoA thioesterase 7 (380 aa)
PCYT1Bphosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis (369 aa)
ACOT9acyl-CoA thioesterase 9; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs (448 aa)
BIRC6baculoviral IAP repeat containing 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the [...] (4857 aa)
ZNF223zinc finger protein 223; May be involved in transcriptional regulation (482 aa)
BIRC8baculoviral IAP repeat containing 8; Protects against apoptosis mediated by BAX (236 aa)
NAIPNLR family, apoptosis inhibitory protein; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at ’Asp-315’ and decreasing the rate of auto proteolysis at ’Asp-330’. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor- neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apopt [...] (1403 aa)
PCYT2phosphate cytidylyltransferase 2, ethanolamine; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine (407 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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