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STRINGSTRING
HLA-G HLA-G HLA-C HLA-C HLA-A HLA-A HLA-B HLA-B HLA-DQB2 HLA-DQB2 HLA-DRB5 HLA-DRB5 HLA-DRB1 HLA-DRB1 CD4 CD4 HLA-DQB1 HLA-DQB1 HLA-DOB HLA-DOB HLA-DQA2 HLA-DQA2 HLA-DPB1 HLA-DPB1 INS INS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CD4CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts (458 aa)
INSinsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) (110 aa)
HLA-DRB1major histocompatibility complex, class II, DR beta 1 (266 aa)
HLA-Gmajor histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells (338 aa)
HLA-DQA2major histocompatibility complex, class II, DQ alpha 2 (255 aa)
HLA-DRB5major histocompatibility complex, class II, DR beta 5 (266 aa)
HLA-Cmajor histocompatibility complex, class I, C; Involved in the presentation of foreign antigens to the immune system (By similarity) (366 aa)
HLA-Amajor histocompatibility complex, class I, A; Involved in the presentation of foreign antigens to the immune system (By similarity) (365 aa)
HLA-DQB1major histocompatibility complex, class II, DQ beta 1 (261 aa)
HLA-DOBmajor histocompatibility complex, class II, DO beta (273 aa)
HLA-DQB2major histocompatibility complex, class II, DQ beta 2 (227 aa)
HLA-Bmajor histocompatibility complex, class I, B; Involved in the presentation of foreign antigens to the immune system (By similarity) (362 aa)
HLA-DPB1major histocompatibility complex, class II, DP beta 1 (258 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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