node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | GTPBP4 | ENSP00000338862 | ENSP00000354040 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.988 |
BRIX1 | KIAA0020 | ENSP00000338862 | ENSP00000380982 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | KIAA0020 | 0.989 |
BRIX1 | MKI67IP | ENSP00000338862 | ENSP00000285814 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | MKI67 (FHA domain) interacting nucleolar phosphoprotein | 0.997 |
BRIX1 | MRPL1 | ENSP00000338862 | ENSP00000315017 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | mitochondrial ribosomal protein L1 | 0.403 |
BRIX1 | MRTO4 | ENSP00000338862 | ENSP00000364320 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | 0.994 |
BRIX1 | NOC2L | ENSP00000338862 | ENSP00000317992 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter | 0.993 |
BRIX1 | NOP2 | ENSP00000338862 | ENSP00000382392 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.994 |
BRIX1 | NSA2 | ENSP00000338862 | ENSP00000296802 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NSA2 ribosome biogenesis homolog (S. cerevisiae); Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity) | 0.873 |
BRIX1 | PDCD11 | ENSP00000338862 | ENSP00000358812 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA | 0.993 |
BRIX1 | PES1 | ENSP00000338862 | ENSP00000346725 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.994 |
BRIX1 | RPL10A | ENSP00000338862 | ENSP00000363018 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | ribosomal protein L10a | 0.544 |
BRIX1 | RPL23A | ENSP00000338862 | ENSP00000389103 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity) | 0.737 |
BRIX1 | RPL5 | ENSP00000338862 | ENSP00000359345 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | ribosomal protein L5; Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA | 0.948 |
BRIX1 | SDAD1 | ENSP00000338862 | ENSP00000348596 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity) | 0.940 |
GTPBP4 | BRIX1 | ENSP00000354040 | ENSP00000338862 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | 0.988 |
GTPBP4 | KIAA0020 | ENSP00000354040 | ENSP00000380982 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | KIAA0020 | 0.985 |
GTPBP4 | MKI67IP | ENSP00000354040 | ENSP00000285814 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | MKI67 (FHA domain) interacting nucleolar phosphoprotein | 0.992 |
GTPBP4 | MRTO4 | ENSP00000354040 | ENSP00000364320 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | 0.998 |
GTPBP4 | NOC2L | ENSP00000354040 | ENSP00000317992 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter | 0.985 |
GTPBP4 | NOP2 | ENSP00000354040 | ENSP00000382392 | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.996 |