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HIST1H4E HIST1H4E HIST1H4K HIST1H4K HIST1H4L HIST1H4L HIST1H4F HIST1H4F CECR2 CECR2 HIST1H4I HIST1H4I HIST2H4B HIST2H4B HIST1H4J HIST1H4J HIST1H4C HIST1H4C ASH1L ASH1L KAT2A KAT2A HIST1H4G HIST1H4G BRPF3 BRPF3 HIST2H4A HIST2H4A HIST1H4D HIST1H4D HIST1H4H HIST1H4H HIST4H4 HIST4H4 HIST1H4B HIST1H4B ENSG00000267261 ENSG00000267261 KAT2B KAT2B APTX APTX HIST1H4A HIST1H4A CDK2 CDK2 TSPYL2 TSPYL2 EEF1A1 EEF1A1 CASK CASK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
KAT2AK(lysine) acetyltransferase 2A; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (837 aa)
HIST1H4Ghistone cluster 1, H4g; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity) (98 aa)
CECR2cat eye syndrome chromosome region, candidate 2; Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (1443 aa)
KAT2BK(lysine) acetyltransferase 2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes (832 aa)
CDK2cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] (298 aa)
HIST1H4Hhistone cluster 1, H4h (103 aa)
EEF1A1eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (462 aa)
HIST1H4Dhistone cluster 1, H4d (103 aa)
HIST1H4Ihistone cluster 1, H4i (103 aa)
HIST1H4Jhistone cluster 1, H4j (103 aa)
HIST1H4Lhistone cluster 1, H4l (103 aa)
HIST1H4Khistone cluster 1, H4k (103 aa)
BRPF3bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (1205 aa)
HIST4H4histone cluster 4, H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (103 aa)
HIST1H4Ahistone cluster 1, H4a (103 aa)
HIST1H4Ehistone cluster 1, H4e (103 aa)
HIST2H4Bhistone cluster 2, H4b (103 aa)
HIST2H4Ahistone cluster 2, H4a (103 aa)
TSPYL2TSPY-like 2; Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression (693 aa)
HIST1H4Bhistone cluster 1, H4b (103 aa)
HIST1H4Fhistone cluster 1, H4f (103 aa)
HIST1H4Chistone cluster 1, H4c (103 aa)
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
APTXaprataxin (342 aa)
ASH1Lash1 (absent, small, or homeotic)-like (Drosophila); Histone methyltransferase specifically methylating ’Lys- 36’ of histone H3 (H3K36me) (2964 aa)
ENSG00000267261Ras-related protein Rab-5C (282 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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