node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BGN | ELN | ENSP00000327336 | ENSP00000252034 | biglycan; May be involved in collagen fiber assembly (By similarity) | elastin | 0.566 |
BGN | MFAP2 | ENSP00000327336 | ENSP00000364685 | biglycan; May be involved in collagen fiber assembly (By similarity) | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.591 |
COL4A3 | FBLN2 | ENSP00000379823 | ENSP00000384169 | collagen, type IV, alpha 3 (Goodpasture antigen) | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent | 0.580 |
COL4A3 | MFAP2 | ENSP00000379823 | ENSP00000364685 | collagen, type IV, alpha 3 (Goodpasture antigen) | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.576 |
EFEMP1 | EFEMP2 | ENSP00000347596 | ENSP00000309953 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | EGF containing fibulin-like extracellular matrix protein 2 | 0.902 |
EFEMP1 | FBLN1 | ENSP00000347596 | ENSP00000331544 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | fibulin 1 | 0.914 |
EFEMP1 | FBLN2 | ENSP00000347596 | ENSP00000384169 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent | 0.910 |
EFEMP1 | FBLN5 | ENSP00000347596 | ENSP00000345008 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | 0.904 |
EFEMP1 | MFAP1 | ENSP00000347596 | ENSP00000267812 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 1; Component of the elastin-associated microfibrils | 0.921 |
EFEMP1 | MFAP2 | ENSP00000347596 | ENSP00000364685 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 2; Component of the elastin-associated microfibrils | 0.927 |
EFEMP1 | MFAP3 | ENSP00000347596 | ENSP00000322956 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 3; Component of the elastin-associated microfibrils | 0.900 |
EFEMP1 | MFAP4 | ENSP00000347596 | ENSP00000378957 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions | 0.905 |
EFEMP1 | MFAP5 | ENSP00000347596 | ENSP00000352455 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | microfibrillar associated protein 5; Component of the elastin-associated microfibrils | 0.922 |
EFEMP2 | EFEMP1 | ENSP00000309953 | ENSP00000347596 | EGF containing fibulin-like extracellular matrix protein 2 | EGF containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth | 0.902 |
EFEMP2 | FBLN1 | ENSP00000309953 | ENSP00000331544 | EGF containing fibulin-like extracellular matrix protein 2 | fibulin 1 | 0.911 |
EFEMP2 | FBLN2 | ENSP00000309953 | ENSP00000384169 | EGF containing fibulin-like extracellular matrix protein 2 | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent | 0.909 |
EFEMP2 | FBLN5 | ENSP00000309953 | ENSP00000345008 | EGF containing fibulin-like extracellular matrix protein 2 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | 0.957 |
EFEMP2 | FBN1 | ENSP00000309953 | ENSP00000325527 | EGF containing fibulin-like extracellular matrix protein 2 | fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively | 0.641 |
EFEMP2 | LOX | ENSP00000309953 | ENSP00000231004 | EGF containing fibulin-like extracellular matrix protein 2 | lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression | 0.989 |
EFEMP2 | LOXL1 | ENSP00000309953 | ENSP00000261921 | EGF containing fibulin-like extracellular matrix protein 2 | lysyl oxidase-like 1; Active on elastin and collagen substrates (By similarity) | 0.418 |