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RAB40A RAB40A RAB10 RAB10 RAB40AL RAB40AL RAB8A RAB8A RAB3IL1 RAB3IL1 RAB8B RAB8B ENSG00000258052 ENSG00000258052 RAB3IP RAB3IP RAB5A RAB5A RAB44 RAB44 RAB4A RAB4A KIF3C KIF3C RAB15 RAB15 VHL VHL RAB40C RAB40C MAP3K10 MAP3K10 KIF3B KIF3B UBC UBC KIFAP3 KIFAP3 KIF3A KIF3A MAP3K11 MAP3K11 NEDD4L NEDD4L ARHGEF10 ARHGEF10 KIF15 KIF15 KIF26A KIF26A IFT20 IFT20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
RAB40ALRAB40A, member RAS oncogene family-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (278 aa)
RAB44RAB44, member RAS oncogene family (154 aa)
RAB40CRAB40C, member RAS oncogene family; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (281 aa)
MAP3K10mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway (By similarity) (954 aa)
VHLvon Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (213 aa)
RAB10RAB10, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transpo [...] (200 aa)
KIF3Ckinesin family member 3C; Microtubule-based anterograde translocator for membranous organelles (By similarity) (793 aa)
RAB15RAB15, member RAS oncogene family; May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal (By similarity) (208 aa)
RAB5ARAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension (215 aa)
RAB8ARAB8A, member RAS oncogene family; May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization (207 aa)
RAB40ARAB40A, member RAS oncogene family; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (277 aa)
MAP3K11mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (847 aa)
RAB8BRAB8B, member RAS oncogene family; May be involved in vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (By similarity) (207 aa)
KIF15kinesin family member 15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity) (1388 aa)
ARHGEF10Rho guanine nucleotide exchange factor (GEF) 10; May play a role in developmental myelination of peripheral nerves (1344 aa)
UBCubiquitin C (685 aa)
IFT20intraflagellar transport 20 homolog (Chlamydomonas); Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (148 aa)
KIFAP3kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity) (792 aa)
RAB4ARAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (218 aa)
KIF3Bkinesin family member 3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity) (747 aa)
KIF3Akinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) (699 aa)
RAB3IL1RAB3A interacting protein (rabin3)-like 1; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B (382 aa)
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (975 aa)
KIF26Akinesin family member 26A; Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity (By similarity) (1882 aa)
RAB3IPRAB3A interacting protein (rabin3) (476 aa)
ENSG00000258052Uncharacterized protein (76 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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