node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | ACAT1 | ENSP00000333664 | ENSP00000265838 | acetyl-CoA acyltransferase 1 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.924 |
ACAA1 | ACAT2 | ENSP00000333664 | ENSP00000356015 | acetyl-CoA acyltransferase 1 | acetyl-CoA acetyltransferase 2 | 0.911 |
ACAA1 | AUH | ENSP00000333664 | ENSP00000364883 | acetyl-CoA acyltransferase 1 | AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.753 |
ACAA1 | HMGCL | ENSP00000333664 | ENSP00000363614 | acetyl-CoA acyltransferase 1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.931 |
ACAA1 | HMGCS1 | ENSP00000333664 | ENSP00000322706 | acetyl-CoA acyltransferase 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.984 |
ACAA1 | HMGCS2 | ENSP00000333664 | ENSP00000358414 | acetyl-CoA acyltransferase 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.986 |
ACAA1 | UBC | ENSP00000333664 | ENSP00000344818 | acetyl-CoA acyltransferase 1 | ubiquitin C | 0.534 |
ACAA2 | ACAT1 | ENSP00000285093 | ENSP00000265838 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.972 |
ACAA2 | ACAT2 | ENSP00000285093 | ENSP00000356015 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | acetyl-CoA acetyltransferase 2 | 0.908 |
ACAA2 | AUH | ENSP00000285093 | ENSP00000364883 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.790 |
ACAA2 | HMGCL | ENSP00000285093 | ENSP00000363614 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.927 |
ACAA2 | HMGCS1 | ENSP00000285093 | ENSP00000322706 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.983 |
ACAA2 | HMGCS2 | ENSP00000285093 | ENSP00000358414 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.984 |
ACAA2 | UBC | ENSP00000285093 | ENSP00000344818 | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | ubiquitin C | 0.519 |
ACAT1 | ACAA1 | ENSP00000265838 | ENSP00000333664 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acyltransferase 1 | 0.924 |
ACAT1 | ACAA2 | ENSP00000265838 | ENSP00000285093 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage | 0.972 |
ACAT1 | ACAT2 | ENSP00000265838 | ENSP00000356015 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | acetyl-CoA acetyltransferase 2 | 0.841 |
ACAT1 | AUH | ENSP00000265838 | ENSP00000364883 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | AU RNA binding protein/enoyl-CoA hydratase; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5’-AUUUA-3’ motifs | 0.760 |
ACAT1 | HADHB | ENSP00000265838 | ENSP00000325136 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit | 0.929 |
ACAT1 | HMGCL | ENSP00000265838 | ENSP00000363614 | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.936 |