| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KLHDC5 | STXBP4 | ENSP00000370671 | ENSP00000365530 | kelch domain containing 5; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis | syntaxin binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity) | 0.571 |
| LNPEP | SLC2A4 | ENSP00000231368 | ENSP00000320935 | leucyl/cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.986 |
| LNPEP | STX4 | ENSP00000231368 | ENSP00000317714 | leucyl/cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.906 |
| LNPEP | STXBP4 | ENSP00000231368 | ENSP00000365530 | leucyl/cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain | syntaxin binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity) | 0.900 |
| LNPEP | VAMP2 | ENSP00000231368 | ENSP00000314214 | leucyl/cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.922 |
| SLC2A4 | LNPEP | ENSP00000320935 | ENSP00000231368 | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | leucyl/cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain | 0.986 |
| SLC2A4 | STX2 | ENSP00000320935 | ENSP00000376178 | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm | 0.440 |
| SLC2A4 | STX3 | ENSP00000320935 | ENSP00000338562 | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones | 0.479 |
| SLC2A4 | STX4 | ENSP00000320935 | ENSP00000317714 | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.973 |
| SLC2A4 | STXBP4 | ENSP00000320935 | ENSP00000365530 | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | syntaxin binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity) | 0.961 |
| SLC2A4 | VAMP2 | ENSP00000320935 | ENSP00000314214 | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.976 |
| STX19 | VAMP2 | ENSP00000320679 | ENSP00000314214 | syntaxin 19 | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.809 |
| STX1A | VAMP2 | ENSP00000222812 | ENSP00000314214 | syntaxin 1A (brain) | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.989 |
| STX2 | SLC2A4 | ENSP00000376178 | ENSP00000320935 | syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.440 |
| STX2 | VAMP2 | ENSP00000376178 | ENSP00000314214 | syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.980 |
| STX3 | SLC2A4 | ENSP00000338562 | ENSP00000320935 | syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.479 |
| STX3 | STX4 | ENSP00000338562 | ENSP00000317714 | syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.885 |
| STX3 | VAMP2 | ENSP00000338562 | ENSP00000314214 | syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.989 |
| STX4 | LNPEP | ENSP00000317714 | ENSP00000231368 | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | leucyl/cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain | 0.906 |
| STX4 | SLC2A4 | ENSP00000317714 | ENSP00000320935 | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.973 |
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