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STRINGSTRING
PPP3CC PPP3CC PPP5C PPP5C LRGUK LRGUK PPP2CB PPP2CB PPP1CB PPP1CB LRRC61 LRRC61 PPP1CA PPP1CA PPP1CC PPP1CC LRRC56 LRRC56 PPP1R7 PPP1R7 AURKB AURKB LRRC46 LRRC46 AURKA AURKA LRRC23 LRRC23 AURKC AURKC PPP1R11 PPP1R11 LRRC6 LRRC6 LRRC43 LRRC43 DNAL1 DNAL1 LRRIQ3 LRRIQ3 LRRIQ1 LRRIQ1 LRRC49 LRRC49 CEP97 CEP97 LRRCC1 LRRCC1 LRRC48 LRRC48 LRRC9 LRRC9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
LRRC23leucine rich repeat containing 23 (343 aa)
PPP5Cprotein phosphatase 5, catalytic subunit; May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1 (499 aa)
AURKAaurora kinase A; Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, ND [...] (403 aa)
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (309 aa)
PPP1R7protein phosphatase 1, regulatory subunit 7; Regulatory subunit of protein phosphatase 1 (By similarity) (360 aa)
PPP3CCprotein phosphatase 3, catalytic subunit, gamma isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin (512 aa)
LRRC6leucine rich repeat containing 6; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility (466 aa)
LRRC49leucine rich repeat containing 49 (686 aa)
LRRC46leucine rich repeat containing 46 (321 aa)
LRRC56leucine rich repeat containing 56 (542 aa)
LRGUKleucine-rich repeats and guanylate kinase domain containing (825 aa)
PPP1CBprotein phosphatase 1, catalytic subunit, beta isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during [...] (327 aa)
AURKCaurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at ’Ser-10’ and ’Ser-28’. Phosphorylates TA [...] (309 aa)
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] (341 aa)
LRRC48leucine rich repeat containing 48 (523 aa)
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] (323 aa)
LRRC61leucine rich repeat containing 61 (259 aa)
CEP97centrosomal protein 97kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome (865 aa)
LRRC43leucine rich repeat containing 43 (656 aa)
LRRIQ3leucine-rich repeats and IQ motif containing 3 (624 aa)
LRRCC1leucine rich repeat and coiled-coil centrosomal protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis (1032 aa)
PPP1R11protein phosphatase 1, regulatory (inhibitor) subunit 11 (126 aa)
LRRIQ1leucine-rich repeats and IQ motif containing 1 (1722 aa)
DNAL1dynein, axonemal, light chain 1 (190 aa)
LRRC9leucine rich repeat containing 9 (1453 aa)
AURKBaurora kinase B (344 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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