node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HMGCR | SOAT1 | ENSP00000287936 | ENSP00000356591 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase | 0.729 |
HMGCR | UBC | ENSP00000287936 | ENSP00000344818 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | ubiquitin C | 0.999 |
HMGCR | UBIAD1 | ENSP00000287936 | ENSP00000366006 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | UbiA prenyltransferase domain containing 1; Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2- methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of [...] | 0.920 |
HRAS | KRAS | ENSP00000309845 | ENSP00000256078 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | NRAS | ENSP00000309845 | ENSP00000358548 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
HRAS | UBC | ENSP00000309845 | ENSP00000344818 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | ubiquitin C | 0.863 |
HRAS | VEGFA | ENSP00000309845 | ENSP00000361125 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | vascular endothelial growth factor A | 0.926 |
KRAS | HRAS | ENSP00000256078 | ENSP00000309845 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | NRAS | ENSP00000256078 | ENSP00000358548 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
KRAS | UBC | ENSP00000256078 | ENSP00000344818 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | ubiquitin C | 0.972 |
KRAS | VEGFA | ENSP00000256078 | ENSP00000361125 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | vascular endothelial growth factor A | 0.923 |
LIPA | UBC | ENSP00000337354 | ENSP00000344818 | lipase A, lysosomal acid, cholesterol esterase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation | ubiquitin C | 0.520 |
LIPF | UBC | ENSP00000377900 | ENSP00000344818 | lipase, gastric | ubiquitin C | 0.702 |
NRAS | HRAS | ENSP00000358548 | ENSP00000309845 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
NRAS | KRAS | ENSP00000358548 | ENSP00000256078 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.901 |
NRAS | UBC | ENSP00000358548 | ENSP00000344818 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | ubiquitin C | 0.941 |
NRAS | VEGFA | ENSP00000358548 | ENSP00000361125 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | vascular endothelial growth factor A | 0.923 |
SOAT1 | HMGCR | ENSP00000356591 | ENSP00000287936 | sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | 0.729 |
SOAT1 | UBC | ENSP00000356591 | ENSP00000344818 | sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase | ubiquitin C | 0.942 |
SOAT1 | UBIAD1 | ENSP00000356591 | ENSP00000366006 | sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase | UbiA prenyltransferase domain containing 1; Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2- methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of [...] | 0.628 |