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RILPL1 RILPL1 PHKB PHKB PHKA2 PHKA2 CORO2B CORO2B PHKG1 PHKG1 PHKG2 PHKG2 PHKA1 PHKA1 CORO6 CORO6 CORO2A CORO2A UBC UBC CORO1B CORO1B CORO1C CORO1C CORO1A CORO1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
CORO1Acoronin, actin binding protein, 1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (461 aa)
CORO1Ccoronin, actin binding protein, 1C; May be involved in cytokinesis, motility, and signal transduction (By similarity) (474 aa)
PHKG1phosphorylase kinase, gamma 1 (muscle); Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity) (387 aa)
PHKBphosphorylase kinase, beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (1093 aa)
CORO1Bcoronin, actin binding protein, 1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity) (489 aa)
CORO2Acoronin, actin binding protein, 2A (525 aa)
CORO6coronin 6 (472 aa)
UBCubiquitin C (685 aa)
PHKA1phosphorylase kinase, alpha 1 (muscle); Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (1223 aa)
RILPL1Rab interacting lysosomal protein-like 1; Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (403 aa)
PHKA2phosphorylase kinase, alpha 2 (liver); Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (1235 aa)
CORO2Bcoronin, actin binding protein, 2B; May play a role in the reorganization of neuronal actin structure (480 aa)
PHKG2phosphorylase kinase, gamma 2 (testis); Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity) (406 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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