Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | MRPL27 | mitochondrial ribosomal protein L27 (148 aa) | ||
 | EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa) | ||
 | CDY2A | chromodomain protein, Y-linked, 2A; May have histone acetyltransferase activity (By similarity) (541 aa) | ||
 | BHMT2 | betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor (363 aa) | ||
 | MRPS5 | mitochondrial ribosomal protein S5 (430 aa) | ||
 | SLC20A1 | solute carrier family 20 (phosphate transporter), member 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus [...] (679 aa) | ||
 | BHMT | betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (406 aa) | ||
 | CDYL2 | chromodomain protein, Y-like 2 (506 aa) | ||
 | CDY1 | chromodomain protein, Y-linked, 1; Has histone acetyltransferase activity, with a preference for histone H4 (554 aa) | ||
 | CDY1B | chromodomain protein, Y-linked, 1B; Has histone acetyltransferase activity, with a preference for histone H4 (554 aa) | ||
 | IQCB1 | IQ motif containing B1; Involved in ciliogenesis (By similarity) (598 aa) | ||
 | VPS39 | vacuolar protein sorting 39 homolog (S. cerevisiae); May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation (875 aa) | ||
 | PTP4A3 | protein tyrosine phosphatase type IVA, member 3; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (173 aa) | ||
 | SLC20A2 | solute carrier family 20 (phosphate transporter), member 2; Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Fun [...] (652 aa) | ||
 | LRRC39 | leucine rich repeat containing 39 (335 aa) | ||
 | PTP4A2 | protein tyrosine phosphatase type IVA, member 2 (167 aa) | ||
 | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (386 aa) | ||
 | MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) (1265 aa) | ||
 | EPRS | glutamyl-prolyl-tRNA synthetase (1512 aa) | ||
 | SOD2 | superoxide dismutase 2, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) (222 aa) | ||
 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis (173 aa) | ||
 | CNNM4 | cyclin M4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function (775 aa) | ||
 | HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit; Bifunctional subunit (763 aa) | ||
 | CDY2B | chromodomain protein, Y-linked, 2B; May have histone acetyltransferase activity (By similarity) (541 aa) | ||
 | CDYL | chromodomain protein, Y-like (544 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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