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GPX5 GPX5 GPX2 GPX2 GPN2 GPN2 SLC7A7 SLC7A7 GPX6 GPX6 SLC7A5 SLC7A5 PLA2G4A PLA2G4A SLC7A11 SLC7A11 FAU FAU GPX1 GPX1 SLC12A9 SLC12A9 ARHGDIA ARHGDIA AMD1 AMD1 SLC7A14 SLC7A14 GPX4 GPX4 ARHGDIB ARHGDIB ARHGDIG ARHGDIG SLC7A10 SLC7A10 SLC12A2 SLC12A2 SLC12A7 SLC12A7 GPX7 GPX7 SLC7A13 SLC7A13 GPX8 GPX8 SLC7A3 SLC7A3 SLC22A12 SLC22A12 GPX3 GPX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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ARHGDIGRho GDP dissociation inhibitor (GDI) gamma; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP (225 aa)
ARHGDIBRho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (201 aa)
SLC7A14solute carrier family 7 (orphan transporter), member 14 (771 aa)
SLC7A10solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10; Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse (523 aa)
SLC7A5solute carrier family 7 (amino acid transporter light chain, L system), member 5; Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. [...] (507 aa)
SLC12A2solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume (1212 aa)
SLC12A7solute carrier family 12 (potassium/chloride transporters), member 7; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters’ cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity) (1083 aa)
ARHGDIARho GDP dissociation inhibitor (GDI) alpha; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) (204 aa)
SLC12A9solute carrier family 12 (potassium/chloride transporters), member 9 (914 aa)
SLC7A11solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate (501 aa)
SLC7A7solute carrier family 7 (amino acid transporter light chain, y+L system), member 7; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes (511 aa)
SLC7A13solute carrier family 7 (anionic amino acid transporter), member 13; Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner (By similarity) (470 aa)
SLC7A3solute carrier family 7 (cationic amino acid transporter, y+ system), member 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner (619 aa)
GPX4glutathione peroxidase 4; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity) (197 aa)
GPX6glutathione peroxidase 6 (olfactory) (221 aa)
GPX7glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (187 aa)
PLA2G4Aphospholipase A2, group IVA (cytosolic, calcium-dependent); Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (749 aa)
AMD1adenosylmethionine decarboxylase 1 (334 aa)
GPN2GPN-loop GTPase 2 (310 aa)
SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions (553 aa)
GPX3glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione (226 aa)
GPX2glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors (190 aa)
GPX5glutathione peroxidase 5 (epididymal androgen-related protein); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids (221 aa)
GPX1glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown (203 aa)
GPX8glutathione peroxidase 8 (putative) (209 aa)
FAUFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (133 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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