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GNA13 GNA13 SYDE2 SYDE2 ARHGAP12 ARHGAP12 ARHGAP40 ARHGAP40 GMIP GMIP STARD8 STARD8 STARD13 STARD13 ARHGAP33 ARHGAP33 ARHGAP1 ARHGAP1 ARHGAP26 ARHGAP26 ARHGEF12 ARHGEF12 SRGAP1 SRGAP1 OPHN1 OPHN1 RHOT2 RHOT2 PLEKHG5 PLEKHG5 ARAP1 ARAP1 FAM13B FAM13B ARHGAP9 ARHGAP9 CHN1 CHN1 ARAP3 ARAP3 ARHGAP19 ARHGAP19 TAGAP TAGAP ARHGAP23 ARHGAP23 RACGAP1 RACGAP1 ARHGAP24 ARHGAP24 ROCK1 ROCK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
FAM13Bfamily with sequence similarity 13, member B (915 aa)
GMIPGEM interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA (970 aa)
ARAP3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin (1544 aa)
ARHGAP26Rho GTPase activating protein 26; GTPase-activating protein for RHOA and CDC42 (814 aa)
RACGAP1Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] (632 aa)
ARHGAP1Rho GTPase activating protein 1; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (439 aa)
ARHGAP33Rho GTPase activating protein 33; May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity) (1126 aa)
RHOT2ras homolog family member T2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) (618 aa)
STARD13StAR-related lipid transfer (START) domain containing 13 (1113 aa)
SYDE2synapse defective 1, Rho GTPase, homolog 2 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (1194 aa)
ARHGAP12Rho GTPase activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (846 aa)
SRGAP1SLIT-ROBO Rho GTPase activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (1085 aa)
OPHN1oligophrenin 1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function (By similarity). Critical for the stabilization of AMPA receptors at postsynaptic sites (By similarity). Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity) (802 aa)
ARHGAP19Rho GTPase activating protein 19 (494 aa)
TAGAPT-cell activation RhoGTPase activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation (731 aa)
ARHGAP40Rho GTPase activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (622 aa)
STARD8StAR-related lipid transfer (START) domain containing 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1 (1103 aa)
PLEKHG5pleckstrin homology domain containing, family G (with RhoGef domain) member 5 (1083 aa)
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (1450 aa)
ARHGAP9Rho GTPase activating protein 9; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix (731 aa)
ARHGAP24Rho GTPase activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...] (748 aa)
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 (1544 aa)
ROCK1Rho-associated, coiled-coil containing protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induc [...] (1354 aa)
CHN1chimerin 1; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance (459 aa)
ARHGAP23Rho GTPase activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (1491 aa)
GNA13guanine nucleotide binding protein (G protein), alpha 13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (377 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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