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STRINGSTRING
REPS1 REPS1 TOPORS TOPORS UBC UBC BRCA1 BRCA1 TUBG1 TUBG1 TUBGCP6 TUBGCP6 BLOC1S2 BLOC1S2 TUBGCP5 TUBGCP5 TUBG2 TUBG2 MZT1 MZT1 CENPJ CENPJ MZT2A MZT2A TUBGCP3 TUBGCP3 TUBGCP4 TUBGCP4 MZT2B MZT2B TUBGCP2 TUBGCP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
TUBGCP6tubulin, gamma complex associated protein 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (1819 aa)
TUBG2tubulin, gamma 2; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity) (451 aa)
TUBG1tubulin, gamma 1; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (451 aa)
TUBGCP2tubulin, gamma complex associated protein 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (902 aa)
REPS1RALBP1 associated Eps domain containing 1 (795 aa)
TUBGCP3tubulin, gamma complex associated protein 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (907 aa)
MZT2Bmitotic spindle organizing protein 2B (158 aa)
TUBGCP5tubulin, gamma complex associated protein 5; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (1024 aa)
MZT2Amitotic spindle organizing protein 2A (158 aa)
UBCubiquitin C (685 aa)
TOPORStopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation (1045 aa)
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. May play a role in [...] (142 aa)
MZT1mitotic spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the centrosome (82 aa)
CENPJcentromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome (1338 aa)
BRCA1breast cancer 1, early onset; E3 ubiquitin-protein ligase that specifically mediates the formation of ’Lys-6’-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Reg [...] (1884 aa)
TUBGCP4tubulin, gamma complex associated protein 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome (666 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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