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GABARAPL2 | GABA(A) receptor-associated protein-like 2; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (By similarity) (117 aa) | |||
EHHADH | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa) | |||
GABARAPL1 | GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles (117 aa) | |||
MAP1LC3B | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) (125 aa) | |||
MTERFD1 | MTERF domain containing 1; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity) (417 aa) | |||
CTBP1 | C-terminal binding protein 1; Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Corepressor targeting diverse transcription regulators such as GLIS2. Has dehydrogenase activity (440 aa) | |||
SENP2 | SUMO1/sentrin/SMT3 specific peptidase 2; Protease that catalyzes two essential functions in the SUMO pathway- processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity) (589 aa) | |||
CTBP2 | C-terminal binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) (985 aa) | |||
TUFM | Tu translation elongation factor, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (455 aa) | |||
YES1 | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific j [...] (543 aa) | |||
UBC | ubiquitin C (685 aa) | |||
SLC25A46 | solute carrier family 25, member 46 (418 aa) | |||
MAP1LC3A | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) (125 aa) | |||
FUNDC1 | FUN14 domain containing 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control (155 aa) | |||
SH3GLB1 | SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (386 aa) | |||
SNX1 | sorting nexin 1; May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (522 aa) |