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ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis (592 aa) | |||
NT5C3 | 5’-nucleotidase, cytosolic III (336 aa) | |||
PDE1B | phosphodiesterase 1B, calmodulin-dependent; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate (536 aa) | |||
NT5E | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities (574 aa) | |||
AK7 | adenylate kinase 7; Adenylate kinase involved in maintaining ciliary structure and function (By similarity). Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP (723 aa) | |||
PDE4A | phosphodiesterase 4A, cAMP-specific (886 aa) | |||
PDE8A | phosphodiesterase 8A (829 aa) | |||
PDE6G | phosphodiesterase 6G, cGMP-specific, rod, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (87 aa) | |||
PDE1A | phosphodiesterase 1A, calmodulin-dependent (545 aa) | |||
PDE4B | phosphodiesterase 4B, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents (736 aa) | |||
UBC | ubiquitin C (685 aa) | |||
PDE4D | phosphodiesterase 4D, cAMP-specific (809 aa) | |||
AK5 | adenylate kinase 5; Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP (562 aa) | |||
AK2 | adenylate kinase 2 (239 aa) | |||
PDE4C | phosphodiesterase 4C, cAMP-specific; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (712 aa) | |||
PNP | purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) (289 aa) | |||
GUK1 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP (241 aa) | |||
PDE6C | phosphodiesterase 6C, cGMP-specific, cone, alpha prime (858 aa) | |||
ENTPD6 | ectonucleoside triphosphate diphosphohydrolase 6 (putative); Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides. Hydrolyzes preferentially nucleoside 5’-diphosphates, nucleoside 5’-triphosphates are hydrolyzed only to a minor extent, there is no hydrolysis of nucleoside 5’-monophosphates. The order of activity with different substrates is GDP > IDP >> UDP = CDP >> ADP (By similarity) (484 aa) | |||
APRT | adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (180 aa) | |||
ITPA | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (194 aa) | |||
NT5M | 5’,3’-nucleotidase, mitochondrial; Dephosphorylates specifically the 5’ and 2’(3’)- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP (228 aa) | |||
PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP (769 aa) | |||
PDE7A | phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction (482 aa) | |||
GMPR2 | guanosine monophosphate reductase 2; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation (366 aa) | |||
ENSG00000250741 | NT5C1B-RDH14 readthrough (602 aa) |