node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP1 | NLRC4 | ENSP00000410076 | ENSP00000354159 | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | NLR family, CARD domain containing 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis | 0.999 |
CSNK2A1 | XK | ENSP00000217244 | ENSP00000367879 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | X-linked Kx blood group (McLeod syndrome); May be involved in sodium-dependent transport of neutral amino acids or oligopeptides | 0.566 |
EDN3 | KEL | ENSP00000337128 | ENSP00000347409 | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | 0.826 |
KEL | EDN3 | ENSP00000347409 | ENSP00000337128 | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | endothelin 3; Endothelins are endothelium-derived vasoconstrictor peptides | 0.826 |
KEL | XK | ENSP00000347409 | ENSP00000367879 | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | X-linked Kx blood group (McLeod syndrome); May be involved in sodium-dependent transport of neutral amino acids or oligopeptides | 0.566 |
NLRC4 | CASP1 | ENSP00000354159 | ENSP00000410076 | NLR family, CARD domain containing 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis | caspase 1, apoptosis-related cysteine peptidase; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis | 0.999 |
PRKCA | XK | ENSP00000408695 | ENSP00000367879 | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | X-linked Kx blood group (McLeod syndrome); May be involved in sodium-dependent transport of neutral amino acids or oligopeptides | 0.566 |
XK | CSNK2A1 | ENSP00000367879 | ENSP00000217244 | X-linked Kx blood group (McLeod syndrome); May be involved in sodium-dependent transport of neutral amino acids or oligopeptides | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.566 |
XK | KEL | ENSP00000367879 | ENSP00000347409 | X-linked Kx blood group (McLeod syndrome); May be involved in sodium-dependent transport of neutral amino acids or oligopeptides | Kell blood group, metallo-endopeptidase; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3 | 0.566 |
XK | PRKCA | ENSP00000367879 | ENSP00000408695 | X-linked Kx blood group (McLeod syndrome); May be involved in sodium-dependent transport of neutral amino acids or oligopeptides | protein kinase C, alpha; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycl [...] | 0.566 |