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GPD1 GPD1 ENSG00000256591 ENSG00000256591 ALDH5A1 ALDH5A1 ALDH8A1 ALDH8A1 ALDH1L2 ALDH1L2 ALDH1L1 ALDH1L1 ALDH1A2 ALDH1A2 ALDH2 ALDH2 ACLY ACLY ALDH3A1 ALDH3A1 ALDH3B2 ALDH3B2 ALDH16A1 ALDH16A1 ALDH1A1 ALDH1A1 ALDH1A3 ALDH1A3 GPD1L GPD1L ALDH3A2 ALDH3A2 UBC UBC DHRS13 DHRS13 ALDH7A1 ALDH7A1 ALDH4A1 ALDH4A1 IFFO2 IFFO2 ALDH1B1 ALDH1B1 SEC63 SEC63 ALDH9A1 ALDH9A1 HSDL1 HSDL1 SDHAF2 SDHAF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
HSDL1hydroxysteroid dehydrogenase like 1 (330 aa)
ALDH3A1aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes (453 aa)
ALDH1A2aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) (518 aa)
ACLYATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
ALDH3B2aldehyde dehydrogenase 3 family, member B2 (385 aa)
ALDH1L2aldehyde dehydrogenase 1 family, member L2 (923 aa)
ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (517 aa)
ALDH8A1aldehyde dehydrogenase 8 family, member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro) (487 aa)
GPD1Lglycerol-3-phosphate dehydrogenase 1-like; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L (351 aa)
ALDH4A1aldehyde dehydrogenase 4 family, member A1 (563 aa)
ALDH16A1aldehyde dehydrogenase 16 family, member A1 (802 aa)
ALDH1A1aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) (501 aa)
GPD1glycerol-3-phosphate dehydrogenase 1 (soluble) (349 aa)
SDHAF2succinate dehydrogenase complex assembly factor 2; Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment (166 aa)
ALDH5A1aldehyde dehydrogenase 5 family, member A1; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) (548 aa)
ALDH1A3aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) (512 aa)
UBCubiquitin C (685 aa)
ALDH3A2aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (508 aa)
ALDH9A1aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction (518 aa)
SEC63SEC63 homolog (S. cerevisiae); Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane (760 aa)
ALDH1B1aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (517 aa)
DHRS13dehydrogenase/reductase (SDR family) member 13; Putative oxidoreductase (Potential) (377 aa)
ALDH1L1aldehyde dehydrogenase 1 family, member L1 (902 aa)
ALDH7A1aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (539 aa)
IFFO2intermediate filament family orphan 2 (517 aa)
ENSG00000256591Uncharacterized protein (163 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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