Your Input:
|
||||
ZP2 | zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (745 aa) | |||
LFNG | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity) (379 aa) | |||
FUT5 | fucosyltransferase 5 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens (374 aa) | |||
ADAM20 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization (776 aa) | |||
GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C (402 aa) | |||
ADAM2 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (735 aa) | |||
ADAM21 | ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients (722 aa) | |||
FUT6 | fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates (359 aa) | |||
LALBA | lactalbumin, alpha-; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins (142 aa) | |||
FUT9 | fucosyltransferase 9 (alpha (1,3) fucosyltransferase); Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides (359 aa) | |||
B3GALT1 | UDP-Gal-betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N- acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues (326 aa) | |||
B3GNT2 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 2; Catalyzes the initiation and elongation of poly-N- acetyllactosamine chains (397 aa) | |||
FUT3 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links (361 aa) | |||
B3GNT1 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 1; Can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans (415 aa) | |||
FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values (365 aa) | |||
B3GNT5 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 5; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during em [...] (378 aa) | |||
B3GNT4 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 4; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (378 aa) | |||
B3GNT3 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides (372 aa) | |||
ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2; Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids (529 aa) | |||
ZP4 | zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor (540 aa) | |||
B3GALT2 | UDP-Gal-betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues (422 aa) | |||
GALT | galactose-1-phosphate uridylyltransferase (379 aa) | |||
B4GALT1 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (398 aa) | |||
FUT2 | fucosyltransferase 2 (secretor status included); Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values (343 aa) | |||
ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (331 aa) | |||
ZP3 | zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation (424 aa) |