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LRRC18 LRRC18 FLRT3 FLRT3 NYX NYX TMPRSS15 TMPRSS15 TNR TNR TNC TNC C1RL C1RL TMPRSS11D TMPRSS11D F9 F9 C1R C1R C1S C1S MASP1 MASP1 MASP2 MASP2 GPR64 GPR64 GPR124 GPR124 KLK14 KLK14 ACR ACR TENM1 TENM1 FLRT1 FLRT1 TNN TNN RXFP1 RXFP1 TMPRSS9 TMPRSS9 GPR125 GPR125 TENM3 TENM3 TENM2 TENM2 HPR HPR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
KLK14kallikrein-related peptidase 14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumo [...] (267 aa)
ACRacrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome (421 aa)
F9coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa (461 aa)
TNNtenascin N; Involved in neurite outgrowth and cell migration in hippocampal explants (By similarity) (1299 aa)
FLRT1fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling (674 aa)
TNRtenascin R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repuls [...] (1358 aa)
TNCtenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 (2201 aa)
C1RLcomplement component 1, r subcomponent-like; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum (487 aa)
TMPRSS11Dtransmembrane protease, serine 11D; May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions (418 aa)
TMPRSS15transmembrane protease, serine 15; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (1019 aa)
C1Rcomplement component 1, r subcomponent (668 aa)
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) (728 aa)
RXFP1relaxin/insulin-like family peptide receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (757 aa)
C1Scomplement component 1, s subcomponent (688 aa)
TMPRSS9transmembrane protease, serine 9; Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln- Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala- Pro-Ala-AMC are not significantly hydrolyzed (1059 aa)
GPR125G protein-coupled receptor 125; Orphan receptor (1321 aa)
FLRT3fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling (649 aa)
NYXnyctalopin (481 aa)
LRRC18leucine rich repeat containing 18; May be involved in the regulation of spermatogenesis and sperm maturation (By similarity) (261 aa)
GPR64G protein-coupled receptor 64 (1017 aa)
MASP2mannan-binding lectin serine peptidase 2 (686 aa)
TENM3teneurin transmembrane protein 3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By sim [...] (2699 aa)
TENM1teneurin transmembrane protein 1; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) (2732 aa)
GPR124G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) (1338 aa)
TENM2teneurin transmembrane protein 2; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer (2774 aa)
HPRhaptoglobin-related protein (348 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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