node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY3 | CALM1 | ENSP00000260600 | ENSP00000349467 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin 1 (phosphorylase kinase, delta) | 0.813 |
ADCY3 | CALML3 | ENSP00000260600 | ENSP00000315299 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | 0.810 |
ADCY3 | CALML5 | ENSP00000260600 | ENSP00000369689 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | 0.810 |
ADCY3 | CALML6 | ENSP00000260600 | ENSP00000304643 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | calmodulin-like 6 | 0.810 |
ADCY3 | CNGA4 | ENSP00000260600 | ENSP00000369268 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.813 |
CALM1 | ADCY3 | ENSP00000349467 | ENSP00000260600 | calmodulin 1 (phosphorylase kinase, delta) | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.813 |
CALM1 | CNGA4 | ENSP00000349467 | ENSP00000369268 | calmodulin 1 (phosphorylase kinase, delta) | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.800 |
CALML3 | ADCY3 | ENSP00000315299 | ENSP00000260600 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.810 |
CALML3 | CNGA4 | ENSP00000315299 | ENSP00000369268 | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.800 |
CALML5 | ADCY3 | ENSP00000369689 | ENSP00000260600 | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.810 |
CALML5 | CNGA4 | ENSP00000369689 | ENSP00000369268 | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.800 |
CALML6 | ADCY3 | ENSP00000304643 | ENSP00000260600 | calmodulin-like 6 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.810 |
CALML6 | CNGA4 | ENSP00000304643 | ENSP00000369268 | calmodulin-like 6 | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.800 |
CLCA1 | CNGA4 | ENSP00000234701 | ENSP00000369268 | chloride channel accessory 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.800 |
CLCA2 | CNGA4 | ENSP00000359596 | ENSP00000369268 | chloride channel accessory 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4 | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.800 |
CLCA4 | CNGA4 | ENSP00000359594 | ENSP00000369268 | chloride channel accessory 4; May be involved in mediating calcium-activated chloride conductance | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | 0.800 |
CNGA4 | ADCY3 | ENSP00000369268 | ENSP00000260600 | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.813 |
CNGA4 | CALM1 | ENSP00000369268 | ENSP00000349467 | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | calmodulin 1 (phosphorylase kinase, delta) | 0.800 |
CNGA4 | CALML3 | ENSP00000369268 | ENSP00000315299 | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | calmodulin-like 3; May be similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinities, to cellular substrates | 0.800 |
CNGA4 | CALML5 | ENSP00000369268 | ENSP00000369689 | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes | 0.800 |