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CSNK1D CSNK1D RRP7A RRP7A RPS26 RPS26 RIOK1 RIOK1 RPS16 RPS16 TSR1 TSR1 RPS21 RPS21 RPS29 RPS29 DHX37 DHX37 PDCD11 PDCD11 DDX49 DDX49 RPS25 RPS25 RPS4X RPS4X MPHOSPH10 MPHOSPH10 NOC4L NOC4L IMP3 IMP3 RPS18 RPS18 UTP11L UTP11L TBL3 TBL3 UTP18 UTP18 UTP6 UTP6 UTP20 UTP20 RPP40 RPP40 DDX52 DDX52 DCAF13 DCAF13 FCF1 FCF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
UTP18UTP18 small subunit (SSU) processome component homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (556 aa)
MPHOSPH10M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (681 aa)
DDX49DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 (483 aa)
RPS16ribosomal protein S16 (146 aa)
UTP20UTP20, small subunit (SSU) processome component, homolog (yeast); Involved in 18S pre-rRNA processing. Associates with U3 snoRNA (2785 aa)
UTP6UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (597 aa)
DDX52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 (599 aa)
DCAF13DDB1 and CUL4 associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (597 aa)
TSR1TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) (804 aa)
DHX37DEAH (Asp-Glu-Ala-His) box polypeptide 37 (1157 aa)
RRP7Aribosomal RNA processing 7 homolog A (S. cerevisiae) (280 aa)
CSNK1Dcasein kinase 1, delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator [...] (415 aa)
IMP3IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (184 aa)
NOC4Lnucleolar complex associated 4 homolog (S. cerevisiae) (516 aa)
FCF1FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) (198 aa)
RPS21ribosomal protein S21 (83 aa)
RPS26ribosomal protein S26 (115 aa)
PDCD11programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (1871 aa)
UTP11LUTP11-like, U3 small nucleolar ribonucleoprotein, (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (253 aa)
RPS4Xribosomal protein S4, X-linked (263 aa)
RIOK1RIO kinase 1 (yeast) (568 aa)
RPP40ribonuclease P/MRP 40kDa subunit; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5’-ends (363 aa)
RPS29ribosomal protein S29 (67 aa)
RPS18ribosomal protein S18 (152 aa)
RPS25ribosomal protein S25 (125 aa)
TBL3transducin (beta)-like 3 (808 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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