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GMIP | GEM interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA (970 aa) | |||
ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (201 aa) | |||
ARHGAP22 | Rho GTPase activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity) (698 aa) | |||
ARHGAP36 | Rho GTPase activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (547 aa) | |||
ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity) (1704 aa) | |||
BCR | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity (1271 aa) | |||
RACGAP1 | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] (632 aa) | |||
TRIP10 | thyroid hormone receptor interactor 10 (545 aa) | |||
RAB11B | RAB11B, member RAS oncogene family; GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis (By similarity) (218 aa) | |||
STARD13 | StAR-related lipid transfer (START) domain containing 13 (1113 aa) | |||
SYDE2 | synapse defective 1, Rho GTPase, homolog 2 (C. elegans); GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (1194 aa) | |||
UBC | ubiquitin C (685 aa) | |||
ARHGAP12 | Rho GTPase activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (846 aa) | |||
SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (1085 aa) | |||
MYO9A | myosin IXA (2548 aa) | |||
RHOT1 | ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) (691 aa) | |||
INPP5B | inositol polyphosphate-5-phosphatase, 75kDa (913 aa) | |||
ARHGAP44 | Rho GTPase activating protein 44; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1 (818 aa) | |||
GDI2 | GDP dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (445 aa) | |||
ARHGAP8 | Rho GTPase activating protein 8 (555 aa) | |||
ARHGAP9 | Rho GTPase activating protein 9; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix (731 aa) | |||
ARHGAP24 | Rho GTPase activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...] (748 aa) | |||
MYO9B | myosin IXB; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho (2022 aa) | |||
ARHGAP35 | Rho GTPase activating protein 35; Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5’- GAGAAAAGAAACTGGAGAAACTC-3’. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor (1499 aa) | |||
ARHGAP25 | Rho GTPase activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (646 aa) | |||
RAB1A | RAB1A, member RAS oncogene family; Probably required for transit of protein from the ER through Golgi compartment. Binds GTP and GDP and possesses intrinsic GTPase activity (205 aa) |