Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | SCT | secretin; Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach (121 aa) | ||
 | OXT | oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin (125 aa) | ||
 | MLNR | motilin receptor; Receptor for motilin (412 aa) | ||
 | GNRH2 | gonadotropin-releasing hormone 2; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones (120 aa) | ||
 | FFAR1 | free fatty acid receptor 1; Receptor for medium and long chain saturated and unsaturated fatty acids. Binding of the ligand increase intracellular calcium concentration and amplify glucose-stimulated insulin secretion. The activity of this receptor is mediated by G- proteins that activate phospholipase C. Seems to act through a G(q) and G(i)-mediated pathway (300 aa) | ||
 | POMC | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa) | ||
 | PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (724 aa) | ||
 | GNRH1 | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones (92 aa) | ||
 | TACR1 | tachykinin receptor 1; This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is- substance P > substance K > neuromedin-K (407 aa) | ||
 | XCR1 | chemokine (C motif) receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level (333 aa) | ||
 | ADRBK1 | adrenergic, beta, receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (689 aa) | ||
 | VIPR1 | vasoactive intestinal peptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38 (457 aa) | ||
 | ADORA2A | adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (412 aa) | ||
 | HTR4 | 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled (428 aa) | ||
 | XCL2 | chemokine (C motif) ligand 2; Chemotactic activity for lymphocytes but not for monocytes or neutrophils (By similarity) (114 aa) | ||
 | ADRB1 | adrenoceptor beta 1; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity (477 aa) | ||
 | EDNRB | endothelin receptor type B (532 aa) | ||
 | EDN1 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides (212 aa) | ||
 | GRPR | gastrin-releasing peptide receptor; Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (384 aa) | ||
 | AVP | arginine vasopressin; Neurophysin 2 specifically binds vasopressin (164 aa) | ||
 | CHRM5 | cholinergic receptor, muscarinic 5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (532 aa) | ||
 | ARNTL | aryl hydrocarbon receptor nuclear translocator-like (625 aa) | ||
 | LPAR2 | lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (351 aa) | ||
 | MLN | motilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle (115 aa) | ||
 | ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (176 aa) | ||
 | GPR68 | G protein-coupled receptor 68; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity) (365 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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