Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | ADCY7 | adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1080 aa) | ||
 | ITPKA | inositol-trisphosphate 3-kinase A (461 aa) | ||
 | PLCB2 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (1185 aa) | ||
 | GRIN2D | glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine (1336 aa) | ||
 | ITPKC | inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity) (683 aa) | ||
 | ITPKB | inositol-trisphosphate 3-kinase B (946 aa) | ||
 | PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (1234 aa) | ||
 | GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) (1484 aa) | ||
 | PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during [...] (327 aa) | ||
 | NOS3 | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) (1203 aa) | ||
 | ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity) (2743 aa) | ||
 | CAMKK2 | calcium/calmodulin-dependent protein kinase kinase 2, beta (588 aa) | ||
 | CAMK2G | calcium/calmodulin-dependent protein kinase II gamma (556 aa) | ||
 | PPP1CA | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] (341 aa) | ||
 | NOS2 | nitric oxide synthase 2, inducible (1153 aa) | ||
 | PDE1A | phosphodiesterase 1A, calmodulin-dependent (545 aa) | ||
 | NOS1 | nitric oxide synthase 1 (neuronal); Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (1468 aa) | ||
 | PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) (1216 aa) | ||
 | RYR1 | ryanodine receptor 1 (skeletal); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Requi [...] (5038 aa) | ||
 | RYR2 | ryanodine receptor 2 (cardiac); Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development (4967 aa) | ||
 | ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (2671 aa) | ||
 | CNGA4 | cyclic nucleotide gated channel alpha 4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity) (575 aa) | ||
 | PHKA2 | phosphorylase kinase, alpha 2 (liver); Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (1235 aa) | ||
 | CALML5 | calmodulin-like 5; Binds calcium. May be involved in terminal differentiation of keratinocytes (146 aa) | ||
 | ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity) (2701 aa) | ||
 | RASGRF1 | Ras protein-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP (1273 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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