Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
SEC14L3 SEC14L3 CLVS2 CLVS2 RLBP1 RLBP1 CLVS1 CLVS1 SEC14L2 SEC14L2 DDX52 DDX52 PLD2 PLD2 MOSPD2 MOSPD2 PLD1 PLD1 SEC14L4 SEC14L4 PISD PISD SEC14L1 SEC14L1 SEC14L5 SEC14L5 ACAP1 ACAP1 UBB UBB BCS1L BCS1L UBC UBC COL4A3BP COL4A3BP ACAP2 ACAP2 ARFGAP1 ARFGAP1 AIFM1 AIFM1 SYS1 SYS1 SMAP1 SMAP1 SMAP2 SMAP2 ELAVL1 ELAVL1 ACAP3 ACAP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
ACAP1ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface (740 aa)
SEC14L3SEC14-like 3 (S. cerevisiae); Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids (400 aa)
SYS1SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae); Involved in protein trafficking. May serve as a receptor for ARFRP1 (156 aa)
SEC14L5SEC14-like 5 (S. cerevisiae) (696 aa)
SEC14L4SEC14-like 4 (S. cerevisiae); Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids (406 aa)
PLD2phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) (933 aa)
PISDphosphatidylserine decarboxylase (375 aa)
RLBP1retinaldehyde binding protein 1; Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the ’visual cycle’ (317 aa)
DDX52DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 (599 aa)
CLVS2clavesin 2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (327 aa)
AIFM1apoptosis-inducing factor, mitochondrion-associated, 1 (613 aa)
UBBubiquitin B (229 aa)
ARFGAP1ADP-ribosylation factor GTPase activating protein 1 (414 aa)
SEC14L2SEC14-like 2 (S. cerevisiae); Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (403 aa)
ACAP2ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) (778 aa)
CLVS1clavesin 1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (354 aa)
PLD1phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) (1074 aa)
UBCubiquitin C (685 aa)
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 3; GTPase-activating protein for the ADP ribosylation factor family (Potential) (834 aa)
BCS1LBC1 (ubiquinol-cytochrome c reductase) synthesis-like; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (419 aa)
SMAP1small ArfGAP 1; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity) (467 aa)
SMAP2small ArfGAP2 (429 aa)
MOSPD2motile sperm domain containing 2 (518 aa)
COL4A3BPcollagen, type IV, alpha 3 (Goodpasture antigen) binding protein (752 aa)
SEC14L1SEC14-like 1 (S. cerevisiae) (719 aa)
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); Involved in 3’-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5’-UUUU[AG]UUU-3’ motif in vitro (326 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: medium (52%)