node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BID | BNC2 | ENSP00000318822 | ENSP00000370047 | BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.419 |
BIK | BNC2 | ENSP00000216115 | ENSP00000370047 | BCL2-interacting killer (apoptosis-inducing); Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.412 |
BNC2 | BID | ENSP00000370047 | ENSP00000318822 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | BH3 interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2 | 0.419 |
BNC2 | BIK | ENSP00000370047 | ENSP00000216115 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | BCL2-interacting killer (apoptosis-inducing); Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX | 0.412 |
BNC2 | IRF6 | ENSP00000370047 | ENSP00000355988 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity) | 0.448 |
BNC2 | RB1 | ENSP00000370047 | ENSP00000267163 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.567 |
BNC2 | SPATA25 | ENSP00000370047 | ENSP00000361597 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | spermatogenesis associated 25; May play a role in spermatogenesis | 0.412 |
IRF6 | BNC2 | ENSP00000355988 | ENSP00000370047 | interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity) | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.448 |
RB1 | BNC2 | ENSP00000267163 | ENSP00000370047 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.567 |
RB1 | SUMO2 | ENSP00000267163 | ENSP00000405965 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | 0.664 |
SPATA25 | BNC2 | ENSP00000361597 | ENSP00000370047 | spermatogenesis associated 25; May play a role in spermatogenesis | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.412 |
SUMO2 | RB1 | ENSP00000405965 | ENSP00000267163 | SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.664 |