Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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 | RPS5 | ribosomal protein S5 (204 aa) | ||
 | NHP2L1 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (128 aa) | ||
 | FBL | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (321 aa) | ||
 | RPL18A | ribosomal protein L18a (176 aa) | ||
 | UTP3 | UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae); Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity) (479 aa) | ||
 | POLR1B | polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) (1135 aa) | ||
 | NOP58 | NOP58 ribonucleoprotein homolog (yeast); Required for 60S ribosomal subunit biogenesis (By similarity) (529 aa) | ||
 | RPS11 | ribosomal protein S11 (158 aa) | ||
 | NEMF | nuclear export mediator factor (1076 aa) | ||
 | RPL15 | ribosomal protein L15 (204 aa) | ||
 | WDR75 | WD repeat domain 75 (830 aa) | ||
 | RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); Involved in ribosome biogenesis (By similarity) (365 aa) | ||
 | IMP3 | IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (184 aa) | ||
 | RPS7 | ribosomal protein S7; Required for rRNA maturation (194 aa) | ||
 | UBC | ubiquitin C (685 aa) | ||
 | HEATR1 | HEAT repeat containing 1; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity) (2144 aa) | ||
 | PDCD11 | programmed cell death 11; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (1871 aa) | ||
 | NOLC1 | nucleolar and coiled-body phosphoprotein 1; Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I (699 aa) | ||
 | UTP11L | UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (253 aa) | ||
 | NOP56 | NOP56 ribonucleoprotein homolog (yeast); Involved in the early to middle stages of 60S ribosomal subunit biogenesis (594 aa) | ||
 | UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast); May be required for ribosome biogenesis (By similarity) (771 aa) | ||
 | NOP2 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase (808 aa) | ||
 | GNL3 | guanine nucleotide binding protein-like 3 (nucleolar); May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity) (549 aa) | ||
 | FTSJ3 | FtsJ homolog 3 (E. coli); Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation (847 aa) | ||
 | EBNA1BP2 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) (361 aa) | ||
 | RPS13 | ribosomal protein S13 (151 aa) | ||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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